Financiado en parte por Egg Nutrition Center
Effects of Egg Consumption and Choline Supplementation on Plasma Choline and Trimethylamine-N-Oxide in a Young Population
Lemos BS, Medina-Vera I, Malysheva OV, Caudill MA, Fernandez ML
Journal of the American College of Nutrition · 34 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- University of Minnesota
- Grupo de la industria
- Egg Nutrition Center
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-05-15 · J Am Coll Nutr · vol. 37 · número 8 · págs. 716–723
- Editorial
- Taylor & Francis
- Citado
- 46 citas · más que el 95% de estudios similares · 5.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Folate and B Vitamins Research · Nutritional Studies and Diet · Cardiovascular Health and Risk Factors
- Palabras clave
- Choline, Crossover study, Internal medicine, Endocrinology, Trimethylamine N-oxide, Population, Chemistry, Trimethylamine, Medicine, Biochemistry
5 autores
- Bruno S. Lemos🇺🇸University of Connecticut
- Isabel Vera🇺🇸University of Connecticut
- Olga V. Malysheva🇺🇸Cornell University
- Marie A. Caudill🇺🇸Cornell University
- María Luz Fernández🇺🇸 · autor de correspondenciaUniversity of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Plasma trimethylamine-N-oxide (TMAO) concentrations have been associated with cardiovascular disease risk. Eggs are a rich source of choline, which is a precursor of TMAO.Objective: The effects of egg intake versus daily choline supplementation were evaluated on plasma choline and TMAO in a young, healthy population.Methods: Thirty participants (14 males, 16 females; 25.6 ± 2.3 years; body mass index = 24.3 ± 2.9 kg/m2) were enrolled in this 13-week crossover intervention. After a 2-week washout, participants were randomized to consume either 3 eggs/d or a choline bitartrate supplement (∼ 400 mg choline total in eggs or supplement) for 4 weeks. Following a 3-week washout, participants were switched to the alternate treatment. Dietary records were measured at the end of each period. Plasma TMAO and choline were measured at baseline and at the end of each dietary intervention. Gene expression of scavenger receptors associated with plasma TMAO were quantified at the end of each intervention.Results: Compared to the choline supplement, intake of total fat, cholesterol, selenium, and vitamin E were higher (p p p = 0.023) with egg intake, while no changes were observed with choline supplementation. Plasma TMAO levels were not different between dietary treatments or compared to baseline.Conclusions: Dietary choline appears to be more bioavailable via egg consumption when compared to a choline supplement. Plasma TMAO concentrations were not affected in healthy participants after 4 weeks of taking ∼400 mg/d choline either via eggs or choline supplementation.
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