Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial
Nasimi Doost Azgomi R, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nejatbakhsh F, Moini Jazani A, Ahmadi AsrBadr Y, Zomorrodi A
Andrologia · 34 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tabriz University of Medical Sciences
- Universidad u hospital
- University of Tabriz
- Universidad u hospital
- Vice Chancellor for Research of Tabriz University of Medical Sciences
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-05-16 · Andrologia · vol. 50 · número 7 · pág. e13041
- Editorial
- Wiley
- Citado
- 54 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Sperm and Testicular Function · Phytochemicals and Medicinal Plants · Reproductive Health and Technologies
- Palabras clave
- Withania somnifera, pentoxifylline, idiopathic male infertility, semen parameters, sperm count, sperm motility, sperm morphology, semen volume, herbal medicine, traditional medicine
- MeSH
- spermatozoa, humans, withania, infertility, male, pentoxifylline, plant extracts, phosphodiesterase inhibitors, sperm count, treatment outcome, medicine, traditional, drug therapy, combination, sperm motility, adult, iran, male, young adult
8 autores
- Ramin Nasimi Doost Azgomi🇮🇷Tabriz University of Medical Sciences
- Hossein Nazemiyeh🇮🇷Tabriz University of Medical Sciences; Research Center for Pharmaceutical Nanotechnology
- Homayoun Sadeghi Bazargani🇮🇷Tabriz University of Medical Sciences
- Seyyed Mohammad Bagher Fazljou🇮🇷Tabriz University of Medical Sciences
- Fatemeh Nejatbakhsh🇮🇷Tehran University of Medical Sciences
- Arezoo Moini Jazani🇮🇷Tabriz University of Medical Sciences
- Yadollah Ahmadi Asr Badr🇮🇷Tabriz University of Medical Sciences
- Afshar Zomorrodi🇮🇷 · autor de correspondenciaTabriz University of Medical Sciences; Emam Reza Hospital; Imam Reza Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
In this triple-blind randomised clinical trial, we compared the effects of Withania somnifera and pentoxifylline on the sperm parameters in idiopathic male infertility. One hundred infertile male patients were randomly allocated into either W. somnifera or pentoxifylline groups. Patients in the herbal group received six capsules containing 5 g/daily of W. somnifera root, and subjects in the pentoxifylline group received six capsules containing 800 mg/daily of pentoxifylline and placebo for 90 days. Sperm parameters were analysed at the beginning and end of the study. W. somnifera increased mean sperm count (12.5%) and progressive motility (21.42%) and improved sperm morphology (25.56%) compared to the baseline (p = .04, p = .001 and p = .000 respectively). Moreover, pentoxifylline increased mean semen volume (16.46%), progressive motility (25.97%) and improved sperm morphology (13.28%) versus the baseline (p = .02, p = .003 and p = .01 respectively). Intergroup comparison showed no significant differences between the two groups regarding semen volume (p = .11), sperm count (p = .09), morphology (p = .12) and progressive motility (p = .77) after treatment. No major complication was reported in either of the two groups. W. somnifera, a traditional medicine remedy, improves sperms parameters in idiopathic male infertility without causing adverse effects. Therefore, this medication can be considered to be an alternative to pentoxifylline in this regard.
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