Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
Qin C, Lv J, Guo Y, Bian Z, Si J, Yang L, Chen Y, Zhou Y, Zhang H, Liu J, Chen J, Chen Z, Yu C, Li L, China Kadoorie Biobank Collaborative Group
Heart (British Cardiac Society) · 95 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Universidad u hospital
- University of Oxford
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Organización sin fines de lucro
- Kadoorie Charitable Foundation
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- Medical Research Council
- Gobierno
- Ministry of Science and Technology of the People’s Republic of China
- Subvenciones
- National Natural Science Foundation of China (81390544); National Natural Science Foundation of China (81390540, 81390544, 81390541); Wellcome Trust (212946/Z/18/Z); National Natural Science Foundation of China (104085/Z/14/Z); Wellcome Trust (202922/Z/16/Z, 088158/Z/09/Z, 104085/Z/14/Z); National Key Research and Development Program of China (088158/Z/09/Z); University of Oxford (104085/Z/14/Z); Wellcome Trust (81390544); Wellcome Trust (202922/Z/16/Z); Ministry of Science and Technology of the People's Republic of China (202922/Z/16/Z); National Key Research and Development Program of China (202922/Z/16/Z); Kadoorie Charitable Foundation (81390541); National Natural Science Foundation of China (81390541); National Natural Science Foundation of China (202922/Z/16/Z); National Key Research and Development Program of China (104085/Z/14/Z); Wellcome Trust (088158/Z/09/Z); National Natural Science Foundation of China (088158/Z/09/Z); Ministry of Science and Technology of the People's Republic of China (088158/Z/09/Z); National Natural Science Foundation of China (81390540); Ministry of Science and Technology of the People's Republic of China (81390544); University of Oxford (202922/Z/16/Z); National Key Research and Development Program of China (81390544); Ministry of Science and Technology of the People's Republic of China (81390541); Wellcome Trust (104085/Z/14/Z); Kadoorie Charitable Foundation (202922/Z/16/Z); National Key Research and Development Program of China (81390541); National Key Research and Development Program of China (81390540); Ministry of Science and Technology of the People's Republic of China (81390540); Kadoorie Charitable Foundation (088158/Z/09/Z); Kadoorie Charitable Foundation (104085/Z/14/Z); Kadoorie Charitable Foundation (81390544); Ministry of Science and Technology of the People's Republic of China (104085/Z/14/Z); Wellcome Trust (81390540); Kadoorie Charitable Foundation (81390540); University of Oxford (088158/Z/09/Z); Wellcome Trust (81390541)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-05-21 · Heart · vol. 104 · número 21 · págs. 1756–1763
- Editorial
- BMJ
- Citado
- 130 citas · más que el 99% de estudios similares · 12.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Consumer Attitudes and Food Labeling
- Palabras clave
- Medicine, Hazard ratio, Stroke (engine), Diabetes mellitus, Proportional hazards model, Internal medicine, Lower risk, Disease, Cohort study, Cohort, Confidence interval, Endocrinology
- MeSH
- humans, cardiovascular diseases, prevalence, multivariate analysis, logistic models, proportional hazards models, risk assessment, survival analysis, retrospective studies, cohort studies, risk reduction behavior, age factors, sex factors, eggs, adult, aged, middle aged, china, female, male, stroke
14 autores
- Chenxi Qin🇨🇳🇬🇧Peking University; Faculty of Public Health
- Jun Lv🇨🇳🇬🇧Peking University; Faculty of Public Health
- Canqing Yu🇬🇧🇨🇳Academy of Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College
- Zheng Bian🇬🇧🇨🇳Academy of Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College
- Jiahui Si🇨🇳🇬🇧Peking University; Faculty of Public Health
- Ling Yang🇬🇧University of Oxford; Nuffield Health
- Yiping Chen🇬🇧University of Oxford; Nuffield Health
- Yonglin Zhou🇨🇳Jiangsu Provincial Center for Disease Control and Prevention
- Hao Zhang🇨🇳🇹🇼Liu Zhou Center for Disease Prevention and Control; Taiwan Centers for Disease Control
- Jianjun Liu🇺🇸Community Health Center
- Junshi Chen🇨🇳China National Center for Food Safety Risk Assessment
- Zhengming Chen🇬🇧University of Oxford; Nuffield Health
- Canqing Yu🇨🇳🇬🇧 · autor de correspondenciaPeking University; Faculty of Public Health
- Liming Li🇨🇳🇬🇧 · autor de correspondenciaPeking University; Faculty of Public Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the associations between egg consumption and cardiovascular disease (CVD), ischaemic heart disease (IHD), major coronary events (MCE), haemorrhagic stroke as well as ischaemic stroke.
Methods
During 2004-2008, over 0.5 million adults aged 30-79 years were recruited from 10 diverse survey sites in China. Participants were asked about the frequency of egg consumption and were followed up via linkages to multiple registries and active investigation. Among 461 213 participants free of prior cancer, CVD and diabetes, a total of 83 977 CVD incident cases and 9985 CVD deaths were documented, as well as 5103 MCE. Stratified Cox regression was performed to yield adjusted hazard ratios for CVD endpoints associated with egg consumption.
Results
At baseline, 13.1% of participants reported daily consumption (usual amount 0.76 egg/day) and 9.1% reported never or very rare consumption (usual amount 0.29 egg/day). Compared with non-consumers, daily egg consumption was associated with lower risk of CVD (HR 0.89, 95% CI 0.87 to 0.92). Corresponding multivariate-adjusted HRs (95% CI) for IHD, MCE, haemorrhagic stroke and ischaemic stroke were 0.88 (0.84 to 0.93), 0.86 (0.76 to 0.97), 0.74 (0.67 to 0.82) and 0.90 (0.85 to 0.95), respectively. There were significant dose-response relationships of egg consumption with morbidity of all CVD endpoints (P for linear trend <0.05). Daily consumers also had an 18% lower risk of CVD death and a 28% lower risk of haemorrhagic stroke death compared to non-consumers.
Conclusion
Among Chinese adults, a moderate level of egg consumption (up to <1 egg/day) was significantly associated with lower risk of CVD, largely independent of other risk factors.
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