Financiado en parte por Khoramshahr Oil Company
The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients Undergoing Low Calorie Diet
Shidfar F, Bahrololumi SS, Doaei S, Doaei S, Mohammadzadeh A, Gholamalizadeh M, Mohammadimanesh A
Canadian journal of gastroenterology & hepatology · 36 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Empresa
- Khoramshahr Oil Company
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-01-01 · Can J Gastroenterol Hepatol · vol. 2018 · págs. 1–7
- Editorial
- Pulsus Group
- Citado
- 58 citas · más que el 95% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Alcohol Consumption and Health Effects
- Palabras clave
- extra virgin olive oil, non-alcoholic fatty liver disease, hepatic steatosis, alanine aminotransferase, aspartate aminotransferase, hypocaloric diet, weight loss, liver enzymes, cardiovascular risk
- MeSH
- liver, humans, fatty liver, alanine transaminase, aspartate aminotransferases, ultrasonography, treatment outcome, caloric restriction, diet, reducing, single-blind method, adult, aged, middle aged, female, male, young adult, non-alcoholic fatty liver disease, biomarkers, olive oil
6 autores
- Farzad Shidfar🇮🇷Iran University of Medical Sciences
- Samaneh Sadat Bahrololumi🇮🇷 · autor de correspondenciaIran University of Medical Sciences
- Saeid Doaei🇮🇷North Khorasan University of Medical Sciences
- Assieh Mohammadzadeh🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Maryam Gholamalizadeh🇮🇷Shahid Beheshti University of Medical Sciences
- Ali Mohammadimanesh🇮🇷Hamedan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Coronary artery disease is the most common cause of death in the patients with nonalcoholic fatty liver disease (NAFLD). Studies have shown that there is a strong relation between the increase in the aminotransferase levels and fat accumulation in the liver with cardiovascular complications, independent of all aspects of the metabolic syndrome. This study aimed to examine the effect of virgin olive oil on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the severity of steatosis in the NAFLD patients undergoing a weight-loss diet.
Methods
This clinical trial was carried out on 50 patients with nonalcoholic fatty liver (mean age of 45.91 ± 9.61 years, mean BMI of 29.7 ± 0.58 Kg/m2) and the subjects were randomly assigned to the olive oil group (receiving the equivalent of 20% of their total daily energy requirement from olive oil) or the control group (with normal consumption of oil) for 12 weeks. All the patients received a hypocaloric diet during the study. At the beginning and the end of the study, the serum levels of ALT and AST and liver steatosis were measured.
Findings
A significant decrease in the level of ALT enzymes was observed in the control group at the end of the study (P = 0.004). In the olive oil group, both enzymes decreased compared to baseline measurements (P P < 0.02). The severity of liver steatosis did not change significantly during the study.
Conclusion
The consumption of a low calorie diet enriched with olive oil, along with slight weight reduction, reinforces the desired effects of weight loss in improving the levels of the hepatic enzymes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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