Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D
Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N
British journal of clinical pharmacology · 210 citas
Cómo se estudió
- Diseño
- Ficha de expertos o del gobierno (clasificado por nuestro filtro de IA)
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Gobierno
- BLRD VA
- Subvenciones
- U.S. Department of Veterans Affairs (I01 BX001066); U.S. Department of Veterans Affairs (I01 BX003814)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-05-31 · Br J Clin Pharmacol · vol. 84 · número 10 · págs. 2194–2207
- Editorial
- Wiley
- Citado
- 337 citas · más que el 100% de estudios similares · 22.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 121 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Bone health and osteoporosis research
- Palabras clave
- Vitamin D and neurology, Hypovitaminosis, Osteomalacia, Calcifediol, Consensus conference, vitamin D deficiency, Medicine, Vitamin D-binding protein, Vitamin, Cholecalciferol, Parathyroid hormone, Internal medicine, Chemistry, Endocrinology, Calcium
- MeSH
- humans, vitamin d deficiency, vitamin d, reference standards, practice guidelines as topic, fibroblast growth factor-23, consensus statements as topic
12 autores
- Christopher T. Sempos🇺🇸 · autor de correspondenciaGrace (United States)
- Annemieke C. Heijboer🇳🇱Amsterdam UMC Location University of Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Daniel D. Bikle🇺🇸San Francisco VA Medical Center; University of California, San Francisco
- Jens Bollerslev🇳🇴Oslo University Hospital; University of Oslo
- Roger Bouillon🇧🇪KU Leuven
- Patsy M. Brannon🇺🇸Cornell University
- Hector F. DeLuca🇺🇸University of Wisconsin–Madison
- Glenville Jones🇨🇦Queen's University
- Craig Frank Munns🇦🇺Children's Hospital at Westmead
- John Paul Bilezikian🇺🇸Columbia University
- Andrea Giustina🇮🇹San Raffaele University of Rome
- Neil Binkley🇺🇸University of Wisconsin–Madison; Institute on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14-16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25-hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D3 and 25(OH)D2 ] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH)2 D3 , 3-epi-25(OH)D, 24,25(OH)2 D3, vitamin D-binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml-1 (30 nmol l-1 ) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml-1 and 50 ng ml-1 (50-125 nmol l-1 ) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
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