Effects of nut consumption on selected inflammatory markers: a systematic review and meta-analysis of randomized controlled trials
Xiao Y, Xia J, Ke Y, Cheng J, Yuan J, Wu S, Lv Z, Huang S, Kim JH, Wong SY, Yeoh EK, Colditz GA, Su X
Nutrition (Burbank, Los Angeles County, Calif.) · 27 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Sanming Project of Medicine in Shenzhen
- Gobierno
- Shenzhen Science and Technology Planning Project
- Subvenciones
- Sanming Project of Medicine in Shenzhen (SZSM201611068); National Natural Science Foundation of China (81402672)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-03-27 · Nutrition · vol. 54 · págs. 129–143
- Editorial
- Elsevier BV
- Citado
- 36 citas · más que el 57% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- nut consumption, inflammatory markers, ICAM-1, VCAM-1, mixed nuts, dietary intervention, inflammation
- MeSH
- humans, nuts, inflammation, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, inflammation mediators, diet, eating, adult, middle aged, female, male, randomized controlled trials as topic, biomarkers
13 autores
- Yunjun Xiao🇨🇳Shenzhen Center for Disease Control and Prevention
- Junjie Xia🇨🇳Shenzhen Center for Disease Control and Prevention
- Yuebin Ke🇨🇳Shenzhen Center for Disease Control and Prevention
- Jinquan Cheng🇨🇳Shenzhen Center for Disease Control and Prevention
- Jianhui Yuan🇨🇳Shenzhen Center for Disease Control and Prevention
- Shuang Wu🇨🇳Shenzhen Center for Disease Control and Prevention
- Ziquan Lv🇨🇳Shenzhen Center for Disease Control and Prevention
- Suli Huang🇨🇳Shenzhen Center for Disease Control and Prevention
- Jean H. Kim🇭🇰Chinese University of Hong Kong
- Samuel Yeung Shan Wong🇭🇰Chinese University of Hong Kong
- Eng‐Kiong Yeoh🇭🇰Chinese University of Hong Kong
- Graham A. Colditz🇺🇸 · autor de correspondenciaWashington University in St. Louis; Alvin J. Siteman Cancer Center
- Xuefen Su🇭🇰 · autor de correspondenciaChinese University of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Several randomized controlled trials (RCTs) have assessed the effects of nut consumption on inflammatory markers. However, the results have been inconsistent. The aim of this meta-analysis of RCTs was to quantitatively evaluate the effects of nut consumption on selected inflammatory markers.
Methods
PubMed, Embase, Cochrane Library database, and Google Scholar were searched for published RCTs that reported the effects of nuts on inflammatory markers as primary or secondary outcomes in an adult population (aged ≥18 y). Summary estimates of weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis.
Results
Twenty-three RCTs met the inclusion criteria. Overall, nut consumption significantly reduced the levels of intercellular adhesion molecule (ICAM)-1 (WMD, -0.17; 95% CI, -0.32 to -0.03; P = 0.01), but had no significant effect on other inflammatory markers. In the subgroup analyses by nut types, mixed nuts had a significant effect on ICAM-1 reduction. The significant effect of nuts on ICAM-1 reduction was only observed in parallel, but not crossover RCTs. Additionally, nut consumption significantly reduced ICAM-1 and vascular cell adhesion molecule-1 levels in long-term (≥12 wk), but not short-term (<12 wk) RCTs. No significant heterogeneity or publication bias was observed in the studies included.
Conclusions
Nut consumption significantly reduced ICAM-1 levels, but had no effect on other inflammatory markers. More studies are needed to assess the effects of nuts on inflammation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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