Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli
Bent S, Lawton B, Warren T, Widjaja F, Dang K, Fahey JW, Cornblatt B, Kinchen JM, Delucchi K, Hendren RL
Molecular autism · 92 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Organización sin fines de lucro
- JS Foundation
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-05-29 · Mol Autism · vol. 9 · número 1 · pág. 35
- Editorial
- BioMed Central
- Citado
- 113 citas · más que el 96% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Sirtuins and Resveratrol in Medicine · Tryptophan and brain disorders
- Palabras clave
- Sulforaphane, Autism, Urinary system, Neuropsychology, Neurology, Medicine, Identification (biology), Autism spectrum disorder, Psychiatry, Internal medicine, Biology, Cognition, Botany
- MeSH
- humans, brassica, isothiocyanates, sulfoxides, antioxidants, social behavior, autistic disorder, adolescent, child, female, male, metabolome, young adult, biomarkers
10 autores
- Stephen Bent🇺🇸 · autor de correspondenciaSan Francisco VA Medical Center; University of California, San Francisco; University of California San Francisco Medical Center
- Brittany Lawton🇺🇸University of California, San Francisco
- Tracy L. Warren🇺🇸University of California, San Francisco
- Felicia Widjaja🇺🇸University of California, San Francisco
- Katherine Dang🇺🇸University of California, San Francisco
- Jed W. Fahey🇺🇸Johns Hopkins University
- Brian S. Cornblatt🇺🇸Nutramax Laboratories (United States)
- Jason Michael Kinchen🇺🇸Metabolon (United States)
- Kevin Delucchi🇺🇸University of California, San Francisco
- Robert L. Hendren🇺🇸University of California, San Francisco
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations. Sulforaphane, a supplement with indirect antioxidant effects that are derived from broccoli sprouts and seeds, was recently shown to lead to improvements in behavior and social responsiveness in children with ASD. We conducted the current open-label study to determine if we could identify changes in urinary metabolites that were associated with clinical improvements with the goal of identifying a potential mechanism of action.
Methods
Children and young adults enrolled in a school for children with ASD and related neurodevelopmental disorders were recruited to participate in a 12-week, open-label study of sulforaphane. Fasting urinary metabolites and measures of behavior (Aberrant Behavior Checklist-ABC) and social responsiveness (Social Responsiveness Scale-SRS) were measured at baseline and at the end of the study. Pearson's correlation coefficient was calculated for the pre- to post-intervention change in each of the two clinical scales (ABS and SRS) versus the change in each metabolite.
Results
Fifteen children completed the 12-week study. Mean scores on both symptom measures showed improvements (decreases) over the study period, but only the change in the SRS was significant. The ABC improved - 7.1 points (95% CI - 17.4 to 3.2), and the SRS improved - 9.7 points (95% CI - 18.7 to - 0.8). We identified 77 urinary metabolites that were correlated with changes in symptoms, and they clustered into pathways of oxidative stress, amino acid/gut microbiome, neurotransmitters, hormones, and sphingomyelin metabolism.
Conclusions
Urinary metabolomics analysis is a useful tool to identify pathways that may be involved in the mechanism of action of treatments targeting abnormal physiology in ASD.
Trial registration
This study was prospectively registered at clinicaltrials.gov (NCT02654743) on January 11, 2016.
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