Postoperative cognitive dysfunction and short-term neuroprotection from blueberries: a pilot study
Traupe I, Giacalone M, Agrimi J, Baroncini M, Pomé A, Fabiani D, Danti S, Timpano Sportiello MR, Di Sacco F, Lionetti V, Giunta F, Forfori F
Minerva anestesiologica · 10 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-12-01 · Minerva Anestesiol · vol. 84 · número 12 · págs. 1352–1360
- Editorial
- Edizioni Minerva Medica
- Citado
- 13 citas · más que el 51% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Anesthesia and Neurotoxicity Research · Intensive Care Unit Cognitive Disorders · Cancer, Stress, Anesthesia, and Immune Response
- Palabras clave
- postoperative cognitive dysfunction, general anesthesia, blueberry juice, neuroprotection, verbal memory, divided attention, selective attention, neuropsychological deficits, elective major surgery
- MeSH
- humans, postoperative complications, neuroprotective agents, phytotherapy, anesthesia, general, pilot projects, time factors, aged, fruit and vegetable juices, blueberry plants, cognitive dysfunction
12 autores
- Ippolito Traupe
- Marilù Giacalone🇮🇹IRCCS Ospedale San Raffaele
- Jacopo Agrimi🇮🇹Scuola Superiore Sant'Anna
- Matteo Baroncini🇮🇹Sapienza University of Rome
- Antonella Pomè🇮🇹University of Florence
- Deborah Fabiani
- Sabrina Danti🇮🇹University of Pisa
- Marco R Timpano Sportiello🇮🇹University of Pisa
- Filippo Di Sacco🇮🇹University of Pisa; Scuola Superiore Sant'Anna; Azienda Ospedaliera Universitaria Pisana
- Vincenzo Lionetti🇮🇹National Research Council
- Francesco Giunta🇮🇹University of Pisa; Azienda Ospedaliera Universitaria Pisana
- Francesco Forfori🇮🇹University of Pisa; Azienda Ospedaliera Universitaria Pisana
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
General anesthesia may be a risk factor for post-operative cognitive impairment, which could be counteracted by neuroprotective compounds. The aims of this study were to determine cognitive functions impaired by general anesthesia and to test blueberry juice as a neuroprotective agent against neuropsychological dysfunctions induced by general anesthesia.
Methods
Twenty-six patients undergoing elective major surgery were randomized into two groups, receiving either 500 mL/day of blueberry juice within 14 preoperative days (G1) or to a control group (G0). Neuropsychological tests were performed around 20 days before surgery (T0), as well as both three hours (T1) and 24 hours (T2) after surgery. All the scores were statistically analyzed to find significant differences between groups and within the three times.
Results
The control (G0) group showed a significant decrease in the performance in the Prose Memory Test (P<0.001), the Attentional Matrices Test (P<0.01), and the Trail Making Test Part B (P<0.01) after general anesthesia. Significant differences were reported in the Prose Memory test, T0 versus T1 (P<0.01), T0 versus T2 (P<0.001); in the Trail Making Test Part B, T0 versus T2 (P<0.01); and the Attentional Matrices test, and T0 versus T2 (P<0.001). The G1 group did not show any decrease in the performance of the three tests.
Conclusions
General anesthesia induces a short-term impairment of verbal memory and selective and divided attention. Blueberry compounds may prevent these neuropsychological deficits through a neuroprotective action in patients undergoing general anesthesia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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