Cholecalciferol Injections Are Effective in Hypovitaminosis D After Duodenal Switch: a Randomized Controlled Study
Hultin H, Stevens K, Sundbom M
Obesity surgery · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Uppsala Universitet
- Universidad u hospital
- Uppsala University
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-06-04 · Obes Surg · vol. 28 · número 10 · págs. 3007–3011
- Editorial
- Springer Science+Business Media
- Citado
- 9 citas · más que el 64% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Bariatric Surgery and Outcomes · Vitamin D Research Studies · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Cholecalciferol, Vitamin D and neurology, Duodenal switch, vitamin D deficiency, Internal medicine, Biliopancreatic Diversion, Population, Parathyroid hormone, Vitamin, Endocrinology, Gastroenterology, Weight loss, Obesity, Morbid obesity, Calcium
- MeSH
- humans, vitamin d deficiency, obesity, morbid, cholecalciferol, anastomosis, surgical, bariatric surgery
3 autores
- Hella Hultin🇸🇪Uppsala University
- Katharina Stevens🇸🇪Uppsala University
- Magnus Sundbom🇸🇪 · autor de correspondenciaUppsala University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
By treating obesity, one of the major epidemics of this past century, through bariatric surgery, we may cause complications due to malnourishment in a growing population. At present, vitamin D deficiency is of interest, especially in patients with inferior absorption of fat-soluble nutrients after biliopancreatic diversion with duodenal switch (BPD/DS).
Methods
Twenty BPD/DS patients, approximately 4 years postoperatively, were randomized to either intramuscular supplementation of vitamin D with a single dose of 600,000 IU cholecalciferol, or a control group. Patients were instructed to limit their supplementation to 1400 IU of vitamin D and to avoid the influence of UV-B radiation; the study was conducted when sunlight is limited (December to May).
Results
Despite oral supplementation, a pronounced deficiency in vitamin D was seen (injection 19.3; control 23.2 nmol/l) in both groups. The cholecalciferol injection resulted in elevated 25[OH]D levels at 1 month (65.4 nmol/l), which was maintained at 6 months (67.4 nmol/l). This resulted in normalization of intact parathyroid hormone (PTH) levels. No changes in vitamin D or PTH occurred in the control group.
Conclusions
In BPD/DS patients, having hypovitaminosis D despite full oral supplementation, a single injection of 600,000 IU of cholecalciferol was effective in elevating vitamin D levels and normalizing levels of intact PTH. The treatment is simple and highly effective and thus recommended, especially in cases of reduced UV-B radiation.
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