Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
Cignarella F, Cantoni C, Ghezzi L, Salter A, Dorsett Y, Chen L, Phillips D, Weinstock GM, Fontana L, Cross AH, Zhou Y, Piccio L
Cell metabolism · 472 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- National Multiple Sclerosis Society
- Organización sin fines de lucro
- Longer Life Foundation
- Organización sin fines de lucro
- Foundation for Barnes-Jewish Hospital
- Organización sin fines de lucro
- Fondazione Italiana Sclerosi Multipla
- Gobierno
- National Institutes of Health
- Gobierno
- Office of the Assistant Secretary for Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- National Center for Research Resources
- Gobierno
- NINDS NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); Fondazione Italiana Sclerosi Multipla (2014/R/15); National Multiple Sclerosis Society (2012/B/1); National Multiple Sclerosis Society (JF 2144A2/1); Fondazione Italiana Sclerosi Multipla (2012/B/1); National Institute of Neurological Disorders and Stroke (R01NS102633); National Center for Research Resources (C06 RR014513); National Multiple Sclerosis Society (FG 2010-A1/2)
Según 12 financiadores declarados.
Publicación
- Publicado
- 2018-06-01 · Cell Metab · vol. 27 · número 6 · págs. 1222–1235.e6
- Editorial
- Cell Press
- Citado
- 564 citas · más que el 100% de estudios similares · 23.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 98 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Gut microbiota and health · Multiple Sclerosis Research Studies
- Palabras clave
- intermittent fasting, multiple sclerosis, experimental autoimmune encephalomyelitis, gut microbiota, hypocaloric diet, fecal microbiota transplantation, regulatory T cells, IL-17-producing T cells, adipokines, immunomodulation, Lactobacillaceae, Bacteroidaceae, Prevotellaceae, oxidative stress
- MeSH
- central nervous system, animals, mice, inbred c57bl, humans, mice, bacteroidaceae, lactobacillaceae, multiple sclerosis, encephalomyelitis, autoimmune, experimental, fasting, pilot projects, autoimmunity, adult, middle aged, female, t-lymphocytes, regulatory, adipokines, th17 cells, gastrointestinal microbiome
12 autores
- Francesca Cignarella🇺🇸Washington University in St. Louis
- Claudia Cantoni🇺🇸Washington University in St. Louis
- Laura Ghezzi🇮🇹🇺🇸University of Milan; Washington University in St. Louis; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Amber R. Salter🇺🇸Washington University in St. Louis
- Yair Dorsett🇺🇸The Jackson Laboratory for Genomic Medicine
- Lei Chen🇺🇸The Jackson Laboratory for Genomic Medicine
- Daniel Phillips🇺🇸The Jackson Laboratory for Genomic Medicine
- George M. Weinstock🇺🇸The Jackson Laboratory for Genomic Medicine
- Luigi Fontana🇺🇸🇮🇹Washington University in St. Louis; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy); University of Brescia
- Anne Haney Cross🇺🇸Washington University in St. Louis; Hope Center for Neurological Disorders
- Yanjiao Zhou🇺🇸 · autor de correspondenciaThe Jackson Laboratory for Genomic Medicine; UConn Health
- Laura M. Piccio🇺🇸 · autor de correspondenciaWashington University in St. Louis; Hope Center for Neurological Disorders
Resumen
El texto original del estudio, en el idioma en que se publicó.
Multiple sclerosis (MS) is more common in western countries with diet being a potential contributing factor. Here we show that intermittent fasting (IF) ameliorated clinical course and pathology of the MS model, experimental autoimmune encephalomyelitis (EAE). IF led to increased gut bacteria richness, enrichment of the Lactobacillaceae, Bacteroidaceae, and Prevotellaceae families and enhanced antioxidative microbial metabolic pathways. IF altered T cells in the gut with a reduction of IL-17 producing T cells and an increase in regulatory T cells. Fecal microbiome transplantation from mice on IF ameliorated EAE in immunized recipient mice on a normal diet, suggesting that IF effects are at least partially mediated by the gut flora. In a pilot clinical trial in MS patients, intermittent energy restriction altered blood adipokines and the gut flora resembling protective changes observed in mice. In conclusion, IF has potent immunomodulatory effects that are at least partially mediated by the gut microbiome.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.