The Relationship of Dietary Cholesterol with Serum Low-Density Lipoprotein Cholesterol and Confounding by Reverse Causality: The INTERLIPID Study
Okami Y, Ueshima H, Nakamura Y, Okuda N, Nakagawa H, Sakata K, Saitoh S, Okayama A, Yoshita K, R Choudhury S, Chan Q, Elliott P, Stamler J, Miura K, INTERMAP and INTERLIPID Research Groups
Journal of atherosclerosis and thrombosis · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Alzheimer's Society
- Universidad u hospital
- Imperial College London
- Gobierno
- Public Health England
- Universidad u hospital
- Fukuoka University
- Universidad u hospital
- UK Dementia Research Institute
- Gobierno
- MRC-PHE Centre for Environment and Health
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL050490); Medical Research Council (MR/L01341X/1); Medical Research Council (MR/L01341X/1); MRC-PHE Centre for Environment and Health (MR/L01341X/1); Public Health England (MR/L01341X/1)
Según 10 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-06-08 · J Atheroscler Thromb · vol. 26 · número 2 · págs. 170–182
- Editorial
- Japan Atherosclerosis Society
- Citado
- 8 citas · más que el 79% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC-SA
- Áreas de investigación
- Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Lipoproteins and Cardiovascular Health
- Palabras clave
- Confounding, Causality (physics), Cholesterol, Internal medicine, Medicine, Reverse cholesterol transport, Lipoprotein, Endocrinology
- MeSH
- humans, coronary disease, cholesterol, dietary, prognosis, follow-up studies, cross-sectional studies, education, adult, middle aged, employment, female, male, cholesterol, ldl, biomarkers
14 autores
- Yukiko Okami🇯🇵Shiga University of Medical Science
- Hirotsugu Ueshima🇯🇵Shiga University of Medical Science
- Yasuyuki Nakamura🇯🇵Ryukoku University
- Nagako Okuda🇯🇵University of Human Arts and Sciences
- Hideaki Nakagawa🇯🇵Kanazawa Medical University
- Kiyomi Sakata🇯🇵Iwate Medical University
- Shigeyuki Saitoh🇯🇵Sapporo Medical University
- Akira Okayama🇯🇵Research Institute of Strategy for Prevention (Japan)
- Katsushi Yoshita🇯🇵Osaka City University
- Sohel Reza Choudhury🇧🇩National Heart Foundation Hospital & Research Institute
- Queenie M Chan🇬🇧Imperial College London
- Paul Elliott🇬🇧Imperial College London
- Jeremiah Stamler
- Katsuyuki Miura🇯🇵Shiga University of Medical Science
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population.
Methods
A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40-59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women). Dietary cholesterol was assessed from four 24-h dietary recalls, and LDL-C was measured enzymatically with an auto-analyzer. A standard questionnaire inquired about employment status and education years.
Results
In men, a 1 standard deviation (SD) higher dietary cholesterol was associated with 3.16 mg/dL lower serum LDL-C (P=0.009; unadjusted model). After adjustment for covariates, higher serum LDL-C was estimated per 1 SD higher intake of dietary cholesterol in nonemployed men [self-employed, homemakers, farmers, fishermen, and retired employees; β=＋9.08, 95% confidence interval (CI)=＋0.90-＋17.27] and less educated men (β=＋4.46, 95% CI=－0.97-＋9.90), whereas an inverse association was observed in employed men (β=－3.02, 95% CI=－5.49-－0.54) and more educated men (β=－3.66, 95% CI=－6.25-－1.07).
Conclusions
In men who were nonemployed and less educated, a higher intake of dietary cholesterol was associated with elevated concentrations of serum LDL-C, whereas an inverse association was observed in men who were employed and more educated.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.