Financiado en parte por Innovation Initiative of the Dutch Health Insurance Companies
Impact of acute versus prolonged exercise and dehydration on kidney function and injury
Bongers CCWG, Alsady M, Nijenhuis T, Tulp ADM, Eijsvogels TMH, Deen PMT, Hopman MTE
Physiological reports · 66 citas
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Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Horizon 2020 Framework Programme
- Organización sin fines de lucro
- Stichting voor de Technische Wetenschappen
- Organización sin fines de lucro
- Society of Experimental Laboratory Medicine
- Grupo de la industria
- Innovation Initiative of the Dutch Health Insurance Companies
- Subvenciones
- Stichting voor de Technische Wetenschappen (12864); Horizon 2020 Framework Programme (655502)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-06-01 · Physiol Rep · vol. 6 · número 11 · pág. e13734
- Editorial
- Wiley
- Citado
- 82 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Thermoregulation and physiological responses · Electrolyte and hormonal disorders · Climate Change and Health Impacts
- Palabras clave
- Acute kidney injury, Dehydration, Medicine, Renal function, Function (biology), Internal medicine, Intensive care medicine, Chemistry, Biology, Biochemistry
- MeSH
- kidney, humans, dehydration, glomerular filtration rate, exercise, water-electrolyte balance, adolescent, adult, male, young adult, acute kidney injury, biomarkers
7 autores
- Coen C. W. G. Bongers🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Mohammad Alsady🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Tom Nijenhuis🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Anouk D. M. Tulp🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Thijs M.H. Eijsvogels🇳🇱🇬🇧Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences; Liverpool John Moores University
- Peter M.T. Deen🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Maria T. E. Hopman🇳🇱 · autor de correspondenciaRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Exercise and dehydration may be associated with a compromised kidney function and potential signs of kidney injury. However, the kidney responses to exercise of different durations and hypohydration levels are not yet known. Therefore, we aimed to compare the effects of acute versus prolonged exercise and dehydration on estimated glomerular filtration rate (eGFR) and kidney injury biomarkers in healthy male adults. A total of 35 subjects (23 ± 3 years) were included and invited for two study visits. Visit 1 consisted of a maximal cycling test. On Visit 2, subjects performed a submaximal exercise test at 80% of maximal heart rate until 3% hypohydration. Blood and urine samples were taken at baseline, after 30 min of exercise (acute effects; low level of hypohydration) and after 150 min of exercise or when 3% hypohydration was achieved (prolonged effects, high level of hypohydration). Urinary outcome parameters were corrected for urinary cystatin C, creatinine, and osmolality. Subjects dehydrated on average 0.6 ± 0.3% and 2.9 ± 0.7% after acute and prolonged exercise, respectively (P cystatin C did not differ between baseline and acute exercise (118 ± 11 vs. 116 ± 12 mL/min/1.73 m2 , P = 0.12), whereas eGFRcystatin C was significantly lower after prolonged exercise (103 ± 16 mL/min/1.73 m2 , P 0.05), and elevated osmolality corrected uNGAL concentrations after acute and prolonged exercise (all P-values cystatin C and kidney injury biomarkers, whereas prolonged exercise is associated with a decline in eGFRcystatin C and increased biomarkers for kidney injury.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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