The anti-obesity effect of starch in a whole grain-like structural form
Luo K, Wang X, Zhang G
Food & function · 14 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (31471585)
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-01-01 · Food Funct · vol. 9 · número 7 · págs. 3755–3763
- Editorial
- Royal Society of Chemistry
- Citado
- 22 citas · más que el 79% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Diet and metabolism studies · Food composition and properties · Diet, Metabolism, and Disease
- Palabras clave
- Food science, Whole grains, Starch, Obesity, Chemistry, Mathematics, Medicine, Internal medicine
- MeSH
- animals, mice, inbred c57bl, humans, mice, mice, obese, obesity, starch, ppar alpha, anti-obesity agents, energy metabolism, male, lipogenesis, adipogenesis, lipid metabolism, sterol regulatory element binding protein 1, fatty acid synthases, whole grains
3 autores
- Kaiyun Luo🇨🇳Jiangnan University; State Key Laboratory of Food Science and Technology
- Xufeng Wang🇨🇳Jiangnan University; State Key Laboratory of Food Science and Technology; Fuzhou University
- Genyi Zhang🇨🇳 · autor de correspondenciaJiangnan University; State Key Laboratory of Food Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity is a risk factor for many chronic diseases, and the anti-obesity effect of starch in a whole grain-like structural form (WGLSF) prepared through co-gelation with oat β-glucan and alginate was studied using high-fat (HF) induced obese male C57BL/6J mice. In vitro human fecal fermentation of WGLSF-starch showed a slower rate of fermentation and a higher production of butyric acid (132.0 μmol per 50 mg sample) when compared to the physical mixture counterpart of starch, β-glucan, and alginate (PM) (110.5 μmol per 50 mg) or β-glucan itself (96.2 μmol per 50 mg). The body weight gain of obese mice fed with a HF-WGLSF diet was significantly reduced (42.0% lower than the HF group, 30.2% lower than the physical mixture) with decreased cell size in white adipose tissue and similar levels of serum lipid profiles to the control of the low-fat (LF) group. Western blotting experiments showed the down-regulated lipogenic transcription factor of SREBP-1c and fatty acid synthase (FAS), but the lipid-oxidation related transcription factors of peroxisome proliferator-activated receptor-α (PPAR-α) and phosphorylated AMP-activated protein kinase (p-AMPK) were up-regulated. Energy metabolism analysis revealed increased lipid-sourced energy expenditure with higher heat production and respiratory exchange ratios. Consistently, the expression of hypothalamic pro-opiomelanocortin (POMC), favoring energy expenditure, was increased significantly while the neuropeptide Y (NPY) was reduced. Thus, the increased energy expenditure stimulated by starch in a whole-grain-like structural form is responsible for the reduced body weight gain of obese mice fed with a high fat-based diet.
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