Longitudinal associations of sauna bathing with inflammation and oxidative stress: the KIHD prospective cohort study
Kunutsor SK, Laukkanen T, Laukkanen JA
Annals of medicine · 26 citas
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Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Foundation for Cardiovascular Research
- Universidad u hospital
- Itä-Suomen Yliopisto
- Universidad u hospital
- University Hospitals Bristol NHS Foundation Trust
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- Department of Health and Social Care
- Universidad u hospital
- University of Bristol
- Organización sin fines de lucro
- Sydäntutkimussäätiö
- Gobierno
- National Institute for Health Research (NIHR)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2018-06-13 · Ann Med · vol. 50 · número 5 · págs. 437–442
- Editorial
- Informa
- Citado
- 35 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Thermoregulation and physiological responses · Therapeutic Uses of Natural Elements · Exercise and Physiological Responses
- Palabras clave
- Medicine, Fibrinogen, Internal medicine, C-reactive protein, Bathing, Prospective cohort study, Gastroenterology, Cohort study, Confounding, Inflammation, Pathology
- MeSH
- humans, cardiovascular diseases, inflammation, gamma-glutamyltransferase, c-reactive protein, fibrinogen, leukocyte count, steam bath, risk factors, prospective studies, cross-sectional studies, risk reduction behavior, oxidative stress, time factors, middle aged, finland, female, male, biomarkers
3 autores
- Setor K. Kunutsor🇬🇧 · autor de correspondenciaSouthmead Hospital; National Institute for Health and Care Research; University of Bristol; NIHR Bristol Biomedical Research Centre
- Tanjaniina Laukkanen🇫🇮University of Eastern Finland
- Jari A. Laukkanen🇫🇮University of Eastern Finland; Central Finland Health Care District; University of Jyväskylä
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
We sought to determine cross-sectional and longitudinal associations of frequency of sauna bathing with high sensitivity C-reactive protein (hsCRP), fibrinogen, leucocyte count and gamma-glutamyltransferase (GGT).
Design
Baseline sauna bathing habits were assessed in 2269 men aged 42-61 years. Concentrations of hsCRP, fibrinogen, leucocyte count, and GGT were determined at baseline and 11 years later. The associations of sauna bathing frequency with baseline and 11-year hsCRP, fibrinogen, leucocyte count, and GGT levels were examined using robust multivariate regression analyses.
Results
In baseline analysis, 4-7 sauna sessions/week (compared with 1 sauna session/week) was associated with -0.84 mg/l (95% CI, -1.55, -0.14; p = .019) lower hsCRP; -0.07 g/l (95% CI, -0.15, 0.02; p = .112) lower fibrinogen; and -0.28 × 109/l (95% CI, -0.51, -0.06; p = .015) lower leucocyte count, after multivariable adjustment. In longitudinal analysis, the corresponding estimates were -1.66 mg/l (95% CI, -3.13, -0.19; p = .027); -0.16 g/l (95% CI, -0.31, -0.02; p = .031); and -0.49 × 109/l (95% CI, -0.85, -0.14; p = .007) respectively. Sauna bathing frequency was not associated with GGT at baseline and 11 years.
Conclusion
Observational evidence supports the hypothesis that reduction in inflammation may be one of the pathways linking frequent sauna bathing with decreased risk of acute and chronic disease conditions. KEY MESSAGES Cross-sectional evidence or short-term studies suggest Finnish sauna bathing may exert its beneficial health effects via reduction in inflammation and oxidative stress; however, the long-term effects of sauna bathing on these outcomes are uncertain. In this population-based prospective cohort study, frequent sauna sessions significantly decreased levels of inflammatory markers at baseline and 11-year follow-up; but had no effect on oxidative stress. The health benefits of sauna bathing may in part be mediated via reduced systemic inflammation.
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