Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial
Langella LG, Casalechi HL, Tomazoni SS, Johnson DS, Albertini R, Pallotta RC, Marcos RL, de Carvalho PTC, Leal-Junior ECP
Lasers in medical science · 71 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (310281/2017-2); Fundação de Amparo à Pesquisa do Estado de São Paulo (10/52404-0)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-06-16 · Lasers Med Sci · vol. 33 · número 9 · págs. 1933–1940
- Editorial
- Springer Science+Business Media
- Citado
- 103 citas · más que el 97% de estudios similares · 5.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Biofield Effects and Biophysics · Photodynamic Therapy Research Studies
- Palabras clave
- low-level laser therapy, light-emitting diode therapy, total hip arthroplasty, postoperative pain, postoperative inflammation, hip osteoarthritis, TNF-α, interleukin-6, interleukin-8, cytokines
- MeSH
- humans, inflammation, tumor necrosis factor-alpha, interleukin-6, placebos, pain measurement, arthroplasty, replacement, hip, aged, female, male, acute pain, low-level light therapy
9 autores
- Luciana Gonçalves Langella🇧🇷Universidade Nove de Julho
- Heliodora Leão Casalechi🇧🇷Universidade Nove de Julho
- Shaiane Silva Tomazoni🇧🇷Universidade Cidade de São Paulo
- Douglas Scott Johnson
- Regiane Albertini🇧🇷Universidade Federal de São Paulo
- Rodney Capp Pallotta🇧🇷Universidade Nove de Julho
- Rodrigo Labat Marcos🇧🇷Universidade Nove de Julho
- Paulo de Tarso Camillo de Carvalho🇧🇷Universidade Nove de Julho
- Ernesto César Pinto Leal‐Junior🇧🇷 · autor de correspondenciaUniversidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
When conservative treatments fail, hip osteoarthritis (OA), a chronic degenerative disease characterized by cartilage wear, progressive joint deformity, and loss of function, can result in the need for a total hip arthroplasty (THA). Surgical procedures induced tissue trauma and incite an immune response. Photobiomodulation therapy (PBMt) using low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) has proven effective in tissue repair by modulating the inflammatory process and promoting pain relief. Therefore, the aim of this study was to analyze the immediate effect of PBMt on inflammation and pain of patients undergoing total hip arthroplasty. The study consisted of 18 post-surgical hip arthroplasty patients divided into two groups (n = 9 each) placebo and active PBMt who received one of the treatments in a period from 8 to 12 h following THA surgery. PBMt (active or placebo) was applied using a device consisting of nine diodes (one super-pulsed laser of 905 nm, four infrared LEDs of 875 nm, and four red LEDs 640 nm, 40.3 J per point) applied to 5 points along the incision. Visual analog scale (VAS) and blood samples for analysis of the levels of the cytokines TNF-α, IL-6, and IL-8 were recorded before and after PBMt application. The values for the visual analog scale as well as those in the analysis of TNF-α and IL-8 serum levels decreased in the active PBMt group compared to placebo-control group (p < 0.05). No decrease was observed for IL-6 levels. We conclude that PBMt is effective in decreasing pain intensity and post-surgery inflammation in patients receiving total hip arthroplasty.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.