Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts
McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ, Buring JE, Campbell PT, Clendenen TV, Freedman ND, Gapstur SM, Giovannucci EL, Goodman GG, Haiman CA, Ho GYF, Horst RL, Hou T, Huang WY, Jenab M, Jones ME, Joshu CE, Krogh V, Lee IM, Lee JE, Männistö S, Le Marchand L, Mondul AM, Neuhouser ML, Platz EA, Purdue MP, Riboli E, Robsahm TE, Rohan TE, Sasazuki S, Schoemaker MJ, Sieri S, Stampfer MJ, Swerdlow AJ, Thomson CA, Tretli S, Tsugane S, Ursin G, Visvanathan K, White KK, Wu K, Yaun SS, Zhang X, Willett WC, Gail MH, Ziegler RG, Smith-Warner SA
Journal of the National Cancer Institute · 217 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- World Health Organization
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- NCI
- Gobierno
- NHLBI NIH HHS
- Gobierno
- National Heart, Blood, and Lung Institute
- Gobierno
- National Cancer Institute Intramural Research Program
- Subvenciones
- National Cancer Institute (UM1-CA167462); National Cancer Institute (R03CA183016); National Heart, Lung, and Blood Institute (T32HL125232); National Cancer Institute (U01 CA063673); National Cancer Institute (U01 CA167462); National Cancer Institute (T32CA009001); National Cancer Institute (R03CA212799); National Cancer Institute (P30CA071789); National Cancer Institute (UM1-CA182934); National Cancer Institute (R01CA152071); National Cancer Institute (R25-CA098566)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2018-04-23 · J Natl Cancer Inst · vol. 111 · número 2 · págs. 158–169
- Editorial
- Oxford University Press
- Citado
- 287 citas · más que el 100% de estudios similares · 22.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · PUBLIC-DOMAIN
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Colorectal Cancer Screening and Detection
- Palabras clave
- Vitamin D and neurology, Colorectal cancer, Medicine, Epidemiology, Pooling, Internal medicine, Bone health, vitamin D deficiency, Vitamin, Oncology, Cancer, Environmental health, Gastroenterology, Physiology, Osteoporosis, Bone mineral, Computer science
- MeSH
- humans, colorectal neoplasms, vitamin d deficiency, vitamins, vitamin d, prognosis, risk factors, case-control studies, follow-up studies, prospective studies, aged, middle aged, international agencies, female, male
56 autores
- Marjorie L. McCullough🇺🇸 · autor de correspondenciaAmerican Cancer Society
- Emilie S. Zoltick🇺🇸Boston University; Brigham and Women's Hospital
- Stephanie J. Weinstein🇺🇸National Institutes of Health; National Cancer Institute
- Veronika Fedirko🇺🇸Emory University
- Molin Wang🇺🇸Cancer Research And Biostatistics
- Nancy R. Cook🇺🇸Brigham and Women's Hospital; Harvard University
- A. Heather Eliassen
- Anne Zeleniuch‐JacquotteNYU Langone’s Laura and Isaac Perlmutter Cancer Center
- Claudia Agnoli🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
- Demetrius Albanes🇺🇸National Institutes of Health; National Cancer Institute
- Matthew J Barnett🇺🇸Fred Hutch Cancer Center
- Julie E. Buring🇺🇸Brigham and Women's Hospital; Harvard University
- Peter T. Campbell🇺🇸American Cancer Society
- Tess V. Clendenen🇺🇸New York University
- Neal D. Freedman🇺🇸National Institutes of Health; National Cancer Institute
- Susan M. Gapstur🇺🇸American Cancer Society
- Edward L. Giovannucci🇺🇸Harvard University
- Gary G. Goodman🇺🇸Fred Hutch Cancer Center
- Christopher A. Haiman🇺🇸University of Southern California
- Gloria Y. F. Ho🇺🇸Feinstein Institute for Medical Research
- Ronald L. Horst🇺🇸Heartland Alliance
- Tao Hou🇺🇸Harvard University
- Wen‐Yi Huang🇺🇸National Institutes of Health; National Cancer Institute
- Mazda Jenab🇫🇷Centre international de recherche sur le cancer
- Michael Emlyn Jones🇷🇺Institute of Cytology and Genetics
- Corinne E. Joshu🇺🇸Johns Hopkins University
- Vittorio Krogh🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
- I‐Min Lee🇺🇸Brigham and Women's Hospital; Harvard University
- Jung Eun Lee🇰🇷Seoul National University
- Satu Männistö🇫🇮Finnish Institute for Health and Welfare
- Loı̈c Le Marchand🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Alison M. Mondul🇺🇸University of Michigan
- Marian L. Neuhouser🇺🇸Fred Hutch Cancer Center
- Elizabeth A. Platz🇺🇸Johns Hopkins University
- Mark P. Purdue🇺🇸National Institutes of Health; National Cancer Institute
- Elio Ríboli🇬🇧Imperial College London
- Trude Eid Robsahm🇳🇴Cancer Registry of Norway
- Thomas E. Rohan🇺🇸Albert Einstein College of Medicine
- Shizuka Sasazuki
- Minouk J. Schoemaker🇷🇺Institute of Cytology and Genetics
- Sabina Sieri🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
- Meir J. Stampfer🇺🇸Harvard University
- Anthony J. Swerdlow🇬🇧🇷🇺Institute of Cancer Research; Institute of Cytology and Genetics
- Cynthia A. Thomson🇺🇸University of Arizona
- Steinar Tretli🇳🇴Cancer Registry of Norway
- Schoichiro Tsugane
- Giske Ursin🇺🇸🇳🇴University of Southern California; University of Oslo; Cancer Registry of Norway
- Kala Visvanathan🇺🇸Johns Hopkins University
- Kami K.L. White🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Kana Wu🇺🇸Harvard University
- Shiaw‐Shyuan Yaun🇺🇸Harvard University
- Xuehong Zhang
- Walter Churchill Willett🇺🇸Harvard University
- M H Gail🇺🇸National Institutes of Health; National Cancer Institute
- Regina G. Ziegler🇺🇸National Institutes of Health; National Cancer Institute
- Stephanie A. Smith‐Warner🇺🇸Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health.
Methods
We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations. For 30.1% of participants, 25(OH)D was newly measured. Previously measured 25(OH)D was calibrated to the same assay to permit estimating risk by absolute concentrations. Study-specific relative risks (RRs) for prediagnostic season-standardized 25(OH)D concentrations were calculated using conditional logistic regression and pooled using random effects models.
Results
Compared with the lower range of sufficiency for bone health (50-<62.5 nmol/L), deficient 25(OH)D (<30 nmol/L) was associated with 31% higher colorectal cancer risk (RR = 1.31, 95% confidence interval [CI] = 1.05 to 1.62); 25(OH)D above sufficiency (75-<87.5 and 87.5-<100 nmol/L) was associated with 19% (RR = 0.81, 95% CI = 0.67 to 0.99) and 27% (RR = 0.73, 95% CI = 0.59 to 0.91) lower risk, respectively. At 25(OH)D of 100 nmol/L or greater, risk did not continue to decline and was not statistically significantly reduced (RR = 0.91, 95% CI = 0.67 to 1.24, 3.5% of control participants). Associations were minimally affected when adjusting for body mass index, physical activity, or other risk factors. For each 25 nmol/L increment in circulating 25(OH)D, colorectal cancer risk was 19% lower in women (RR = 0.81, 95% CI = 0.75 to 0.87) and 7% lower in men (RR = 0.93, 95% CI = 0.86 to 1.00) (two-sided Pheterogeneity by sex = .008). Associations were inverse in all subgroups, including colorectal subsite, geographic region, and season of blood collection.
Conclusions
Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non-statistically significant lower risk in men. Optimal 25(OH)D concentrations for colorectal cancer risk reduction, 75-100 nmol/L, appear higher than current IOM recommendations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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