Financiado en parte por Pfizer
Effects of walnut consumption on blood lipids and other cardiovascular risk factors: an updated meta-analysis and systematic review of controlled trials
Guasch-Ferré M, Li J, Hu FB, Salas-Salvadó J, Tobias DK
The American journal of clinical nutrition · 108 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- American Diabetes Association
- Empresa
- Pfizer
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Institutes of Health (DK46200); American Diabetes Association (9-17-CMF-011)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2018-04-18 · Am J Clin Nutr · vol. 108 · número 1 · págs. 174–187
- Editorial
- Elsevier BV
- Citado
- 147 citas · más que el 94% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- walnut consumption, serum lipids, cardiovascular risk factors, total cholesterol, LDL cholesterol, triglycerides, apolipoprotein B, apolipoprotein(a), body weight, blood pressure, dietary intervention, weight gain, Western diet, American diet, Mediterranean diet
- MeSH
- humans, juglans, nuts, cardiovascular diseases, lipids, risk factors
5 autores
- Marta Guasch‐Ferré🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Jun Li🇺🇸Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Deirdre Kay Tobias🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intervention studies suggest that incorporating walnuts into the diet may improve blood lipids without promoting weight gain.
Objective
We conducted a systematic review and meta-analysis of controlled trials evaluating the effects of walnut consumption on blood lipids and other cardiovascular risk factors.
Design
We conducted a comprehensive search of PubMed and EMBASE databases (from database inception to January 2018) of clinical trials comparing walnut-enriched diets with control diets. We performed random-effects meta-analyses comparing walnut-enriched and control diets for changes in pre-post intervention in blood lipids (mmol/L), apolipoproteins (mg/dL), body weight (kg), and blood pressure (mm Hg).
Results
Twenty-six clinical trials with a total of 1059 participants were included. The following weighted mean differences (WMDs) in reductions were obtained for walnut-enriched diets compared with control groups: -6.99 mg/dL (95% CI: -9.39, -4.58 mg/dL; P < 0.001) (3.25% greater reduction) for total blood cholesterol (TC) and -5.51 mg/dL (95% CI: -7.72, -3.29 mg/dL; P < 0.001) (3.73% greater reduction) for low-density lipoprotein (LDL) cholesterol. Triglyceride concentrations were also reduced in walnut-enriched diets compared with control [WMD = -4.69 (95% CI: -8.93, -0.45); P = 0.03; 5.52% greater reduction]. More pronounced reductions in blood lipids were observed when walnut interventions were compared with American and Western diets [WMD for TC = -12.30 (95% CI: -23.17, -1.43) and for LDL = -8.28 (95% CI: -13.04, -3.51); P < 0.001]. Apolipoprotein B (mg/dL) was also reduced significantly more on walnut-enriched diets compared with control groups [WMD = -3.74 (95% CI: -6.51, -0.97); P = 0.008] and a trend towards a reduction was observed for apolipoprotein A [WMD = -2.91 (95% CI: -5.98, 0.08); P = 0.057]. Walnut-enriched diets did not lead to significant differences in weight change (kg) compared with control diets [WMD = -0.12 (95% CI: -2.12, 1.88); P = 0.90], systolic blood pressure (mm Hg) [WMD = -0.72 (95% CI: -2.75, 1.30); P = 0.48], or diastolic blood pressure (mm Hg) [WMD = -0.10 (95% CI: -1.49, 1.30); P = 0.88].
Conclusions
Incorporating walnuts into the diet improved blood lipid profile without adversely affecting body weight or blood pressure.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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