Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials
Vellekkatt F, Menon V
Journal of postgraduate medicine · 96 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-06-20 · J Postgrad Med · vol. 65 · número 2 · págs. 74–80
- Editorial
- Medknow
- Citado
- 136 citas · más que el 98% de estudios similares · 7.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (publicación gratuita)
- Áreas de investigación
- Vitamin D Research Studies · Treatment of Major Depression · Tryptophan and brain disorders
- Palabras clave
- vitamin D supplementation, major depressive disorder, depressive symptoms, antidepressant non-response, vitamin D deficiency, vitamin D deficiency treatment
- MeSH
- humans, vitamin d deficiency, vitamins, vitamin d, treatment outcome, dietary supplements, randomized controlled trials as topic, major depressive disorder
2 autores
- Favaz Vellekkatt🇮🇳Jawaharlal Institute of Post Graduate Medical Education and Research
- Vikas Menon🇮🇳Jawaharlal Institute of Post Graduate Medical Education and Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is a need to develop and periodically evaluate new treatment strategies in major depression due to the high burden of nonresponse and inadequate response to antidepressants.
Aim
We aimed to assess the effect of vitamin D supplementation on depression symptom scores among individuals with clinically diagnosed major depression.
Materials and methods
Electronic search of databases was carried out for published randomized controlled trials in English language, peer-reviewed journals from inception till August 2017. Outcome measure used for effect size calculation was depression symptom scores. Effect sizes for the trials were computed using standardized mean difference (Cohen's d), and I2 test was used to assess sample heterogeneity. Pooled mean effect sizes were derived using both fixed and random-effects model. Critical appraisal of studies was done using the Cochrane risk of bias assessment tool.
Results
A total of four trials involving 948 participants were included in the study. In three trials, the intervention group received oral vitamin D supplementation whereas in one parenteral vitamin D was given. Pooled mean effect size for vitamin D supplementation on depressive symptom ratings in major depression was 0.58 (95% confidence interval, 0.45-0.72). The I2 value for heterogeneity was 0 suggesting low heterogeneity among studies. Egger plot intercept indicated minimal publication bias.
Conclusion
Vitamin D supplementation favorably impacted depression ratings in major depression with a moderate effect size. These findings must be considered tentative owing to the limited number of trials available and inherent methodological bias noted in few of them.
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