Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study
Hashemian M, Murphy G, Etemadi A, Poustchi H, Sharafkhah M, Kamangar F, Pourshams A, Malekshah AF, Khoshnia M, Gharavi A, Hekmatdoost A, Brennan PJ, Boffetta P, Dawsey SM, Abnet CC, Malekzadeh R
British journal of cancer · 14 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- World Health Organization
- Universidad u hospital
- Centre International de Recherche sur le Cancer
- Organización sin fines de lucro
- Cancer Research UK
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Gobierno
- National Cancer Institute
- Subvenciones
- Cancer Research UK (07CN120-B)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-06-25 · Br J Cancer · vol. 119 · número 2 · págs. 176–181
- Editorial
- Springer Nature
- Citado
- 16 citas · más que el 78% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Peanut Plant Research Studies · Oral Health Pathology and Treatment
- Palabras clave
- Medicine, Hazard ratio, Confounding, Confidence interval, Proportional hazards model, Cohort study, Cohort, Population, Incidence (geometry), Nut, Lower risk, Internal medicine, Environmental health
- MeSH
- humans, nuts, diet, proportional hazards models, risk factors, cohort studies, feeding behavior, aged, middle aged, iran, female, male, esophageal squamous cell carcinoma
16 autores
- Maryam Hashemian🇺🇸🇮🇷National Cancer Institute; Sabzevar University of Medical Sciences; Division of Cancer Epidemiology and Genetics; Tehran University of Medical Sciences
- Gwen A Murphy🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Arash Etemadi🇺🇸🇮🇷National Cancer Institute; Division of Cancer Epidemiology and Genetics; Tehran University of Medical Sciences
- Hossein Poustchi🇮🇷Tehran University of Medical Sciences
- Maryam Sharafkhah🇮🇷Tehran University of Medical Sciences
- Farin Kamangar🇮🇷🇺🇸Tehran University of Medical Sciences; Morgan State University
- Akram Pourshams🇮🇷Tehran University of Medical Sciences
- Akbar Fazeltabar Malekshah🇮🇷Tehran University of Medical Sciences
- Masoud Khoshnia🇮🇷Golestan University; Golestan University of Medical Sciences; Tehran University of Medical Sciences
- Abdolsamad Gharavi🇮🇷Golestan University; Golestan University of Medical Sciences; Tehran University of Medical Sciences
- Azita Hekmatdoost🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Paul Brennan🇫🇷Centre international de recherche sur le cancer
- Paolo Boffetta🇺🇸Icahn School of Medicine at Mount Sinai
- Sanford M. Dawsey🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Christian C. Abnet🇺🇸 · autor de correspondenciaNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Reza Malekzadeh🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nut consumption has been inversely associated with gastric cancer incidence in US-based studies, but not with oesophageal cancer. However, there is aetiologic heterogeneity, among oesophageal squamous cell carcinoma (ESCC) cases in low-risk vs. high-risk populations. The objective of this study was to evaluate the association between nut consumption and risk of ESCC in a high-risk population.
Methods
The Golestan Cohort Study enroled 50,045 participants in Northeastern Iran, between 2004 and 2008. Intake of peanuts, walnuts and mixed nuts (including seeds) were assessed using a validated food frequency questionnaire at baseline. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals for subsequent ESCC adjusted for potential confounders. Non-consumers of nuts were used as the reference category and the consumers were categorised into tertiles.
Results
We accrued 280 incident ESCC cases during 337,983 person-years of follow up. Individuals in the highest tertiles of total nut consumption, and mixed nut consumption were significantly associated with lower risk of developing ESCC compared to non-consumers (HR = 0.60, 95% CI = 0.39-0.93, p-trend = 0.02, and HR = 0.52, 95% CI = 0.32-0.84, p trend = 0.002, respectively).
Conclusions
We found a statistically significant inverse association between total nut consumption and the risk of ESCC in this high-risk population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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