Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank
Loftfield E, Cornelis MC, Caporaso N, Yu K, Sinha R, Freedman N
JAMA internal medicine · 138 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- Medical Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- Medical Research Council (MC_PC_17228)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2018-07-02 · JAMA Intern Med · vol. 178 · número 8 · pág. 1086
- Editorial
- American Medical Association
- Citado
- 187 citas · más que el 99% de estudios similares · 13.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista híbrida) · OTHER-OA
- Áreas de investigación
- Coffee research and impacts · Carcinogens and Genotoxicity Assessment · Pharmacogenetics and Drug Metabolism
- Palabras clave
- Medicine, Caffeine, Biobank, Hazard ratio, Demography, Cohort, Prospective cohort study, Population, Environmental health, Internal medicine, Confidence interval, Bioinformatics, Biology
- MeSH
- humans, cardiovascular diseases, caffeine, nutrition surveys, cause of death, survival rate, risk factors, follow-up studies, prospective studies, drinking behavior, life style, polymorphism, genetic, coffee, adult, aged, middle aged, biological specimen banks, female, male, genetic variation, united kingdom
6 autores
- Erikka Loftfield🇺🇸 · autor de correspondenciaNational Institutes of Health; National Cancer Institute
- Marilyn C. Cornelis🇺🇸Northwestern University
- Neil E. Caporaso🇺🇸National Institutes of Health; National Cancer Institute
- Kai Fun Yu🇺🇸National Institutes of Health; National Cancer Institute
- Rashmi R. Sinha🇺🇸National Institutes of Health; National Cancer Institute
- Neal D. Freedman🇺🇸National Institutes of Health; National Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Importance
Prospective cohorts in North America, Europe, and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain.
Objective
To evaluate associations of coffee drinking with mortality by genetic caffeine metabolism score.
Design, setting, and participants
The UK Biobank is a population-based study that invited approximately 9.2 million individuals from across the United Kingdom to participate. We used baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up beginning in 2006 and ending in 2016, to estimate hazard ratios (HRs) for coffee intake and mortality, using multivariable-adjusted Cox proportional hazards models. We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism. Of the 502 641 participants who consented with baseline data, we included those who were not pregnant and had complete data on coffee intake and smoking status (n = 498 134).
Exposures
Total, ground, instant, and decaffeinated coffee intake.
Main outcomes and measures
All-cause and cause-specific mortality.
Results
The mean age of the participants was 57 years (range, 38-73 years); 271 019 (54%) were female, and 387 494 (78%) were coffee drinkers. Over 10 years of follow-up, 14 225 deaths occurred. Coffee drinking was inversely associated with all-cause mortality. Using non-coffee drinkers as the reference group, HRs for drinking less than 1, 1, 2 to 3, 4 to 5, 6 to 7, and 8 or more cups per day were 0.94 (95% CI, 0.88-1.01), 0.92 (95% CI, 0.87-0.97), 0.88 (95% CI, 0.84-0.93), 0.88 (95% CI, 0.83-0.93), 0.84 (95% CI, 0.77-0.92), and 0.86 (95% CI, 0.77-0.95), respectively. Similar associations were observed for instant, ground, and decaffeinated coffee, across common causes of death, and regardless of genetic caffeine metabolism score. For example, the HRs for 6 or more cups per day ranged from 0.70 (95% CI, 0.53-0.94) to 0.92 (95% CI, 0.78-1.10), with no evidence of effect modification across strata of caffeine metabolism score (P = .17 for heterogeneity).
Conclusions and relevance
Coffee drinking was inversely associated with mortality, including among those drinking 8 or more cups per day and those with genetic polymorphisms indicating slower or faster caffeine metabolism. These findings suggest the importance of noncaffeine constituents in the coffee-mortality association and provide further reassurance that coffee drinking can be a part of a healthy diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.