Effects of a hydroalcoholic extract of Juglans regia (walnut) leaves on blood glucose and major cardiovascular risk factors in type 2 diabetic patients: a double-blind, placebo-controlled clinical trial
Rabiei K, Ebrahimzadeh MA, Saeedi M, Bahar A, Akha O, Kashi Z
BMC complementary and alternative medicine · 31 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Mazandaran University of Medical Sciences
- Subvenciones
- Mazandaran University of Medical Sciences (CT-P-92-5670)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-07-04 · BMC Complement Altern Med · vol. 18 · número 1 · pág. 206
- Editorial
- BioMed Central
- Citado
- 50 citas · más que el 89% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Natural Antidiabetic Agents Studies · Medicinal Plant Research · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- Juglans regia, walnut leaf extract, type 2 diabetes, blood glucose, HbA1c, insulin resistance, HOMA-IR, body weight, blood pressure, lipid profile, cardiovascular risk factors, herbal medicine, postprandial blood glucose, serum insulin, body mass index
- MeSH
- humans, juglans, plant leaves, cardiovascular diseases, diabetes mellitus, type 2, cholesterol, blood glucose, lipids, plant extracts, risk factors, blood pressure, adult, aged, aged, 80 and over, middle aged, female, male
6 autores
- Khadijeh Rabiei
- Mohammad Ali Ebrahimzadeh🇮🇷Mazandaran University of Medical Sciences
- Majid Saeedi🇮🇷Mazandaran University of Medical Sciences
- Adele Bahar🇮🇷Mazandaran University of Medical Sciences
- Ozra Akha🇮🇷Mazandaran University of Medical Sciences
- Zahra Kashi🇮🇷 · autor de correspondenciaMazandaran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We aimed to evaluate the effects of a hydroalcoholic extract of Juglans regia L. leaves on blood glucose level and cardiovascular risk factors in type 2 diabetic patients.
Methods
In this randomized, double-blind, placebo-controlled, parallel-group (2 arms) clinical trial, 50 diabetic patients were divided into two groups: treatment group (receive the capsules containing 100 mg J. regia leaf extract) and control group (receive the capsules containing placebo, microcrystallin cellulose). Baseline participant data were matched between the two arms of the study. We administered the prepared capsules to the patients twice daily for 8 weeks. Blood glucose level, glycosylated hemoglobin (HbA1c) level, body weight, body mass index, blood pressure, lipid profile, serum insulin, and insulin resistance were compared between the two groups before and after the intervention. P < 0.05 was considered significant.
Results
After excluding eleven patients, 20 received J. regia leaf extract and 20 patients received placebo. The J. regia leaf extract did not significantly change the blood glucose and insulin resistance condition. However, in this group, body weight, body mass index, and systolic blood pressure significantly decreased compared with the baseline measurements (P = 0.028, P = 0.030, and P = 0.005, respectively). The lipid profile did not change significantly compared with the baseline measurements. In the control group, postprandial glucose and HbA1c levels significantly decreased after the intervention (P = 0.030 and P = 0.028, respectively). The other variables were not significantly different in this group. At the end of the study, the variables were not significantly different between the two groups.
Conclusion
In this double-blind study, 200 mg/d of J. regia leaf extract had no significant effect on blood glucose level and HOMA-IR score in patients with type 2 diabetes. However, the J. regia leaf extract was effective in reducing body weight and blood pressure. An accidental finding of our study was that microcrystalline cellulose, a widely used placebo in clinical trials, led to a reduction in blood glucose level.
Trial registration
Iranian Registry of Clinical Trials (IRCT: 138901203180 N2 , 2010/6/6); retrospectively registered.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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