A Pilot Randomized Trial of Oral Magnesium Supplementation on Supraventricular Arrhythmias
Lutsey PL, Chen LY, Eaton A, Jaeb M, Rudser KD, Neaton JD, Alonso A
Nutrients · 23 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Organización sin fines de lucro
- American Heart Association-American Stroke Association
- Subvenciones
- American Heart Association (16EIA26410001)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-07-10 · Nutrients · vol. 10 · número 7 · pág. 884
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 26 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Atrial Fibrillation Management and Outcomes · Cardiac Arrhythmias and Treatments · Magnesium in Health and Disease
- Palabras clave
- Medicine, Placebo, Magnesium, Randomized controlled trial, Atrial fibrillation, Ambulatory, Pill, Confidence interval, Internal medicine, Anesthesia, Pharmacology
- MeSH
- humans, atrial fibrillation, atrial premature complexes, magnesium oxide, anti-arrhythmia agents, electrocardiography, ambulatory, treatment outcome, administration, oral, feasibility studies, pilot projects, double-blind method, predictive value of tests, transducers, heart rate, time factors, dietary supplements, signal processing, computer-assisted, aged, middle aged, minnesota, female, male, medication adherence
7 autores
- Pamela L. Lutsey🇺🇸 · autor de correspondenciaUniversity of Minnesota
- Lin Y. Chen🇺🇸University of Minnesota
- Anne A. Eaton🇺🇸University of Minnesota
- Melanie A. Jaeb🇺🇸University of Minnesota
- Kyle D. Rudser🇺🇸University of Minnesota
- James D. Neaton🇺🇸University of Minnesota
- Álvaro Alonso🇺🇸Emory University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Low magnesium may increase the risk of atrial fibrillation. We conducted a double-blind pilot randomized trial to assess adherence to oral magnesium supplementation (400 mg of magnesium oxide daily) and a matching placebo, estimate the effect on circulating magnesium concentrations, and evaluate the feasibility of using an ambulatory heart rhythm monitoring device (ZioPatch) for assessing premature atrial contractions. A total of 59 participants were randomized; 73% were women, and the mean age was 62 years. A total of 98% of the participants completed the follow-up. In the magnesium supplement group, 75% of pills were taken, and in the placebo group, 83% were taken. The change in magnesium concentrations was significantly greater for those given the magnesium supplements than for those given the placebo (0.07; 95% confidence interval: 0.03, 0.12 mEq/L; p = 0.002). The ZioPatch wear time was approximately 13 of the requested 14 days at baseline and follow-up. There was no difference by intervention assignment in the change in log premature atrial contractions burden, glucose, or blood pressure. Gastrointestinal changes were more common among the participants assigned magnesium (50%) than among those assigned the placebo (7%), but only one person discontinued participation. In sum, compliance with the oral magnesium supplementation was very good, and acceptance of the ZioPatch monitoring was excellent. These findings support the feasibility of a larger trial for atrial fibrillation (AF) prevention with oral magnesium supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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