The effects of photodynamic and low-level laser therapy for treatment of oral lichen planus-A systematic review and meta-analysis
Hoseinpour Jajarm H, Asadi R, Bardideh E, Shafaee H, Khazaei Y, Emadzadeh M
Photodiagnosis and photodynamic therapy · 35 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-07-10 · Photodiagnosis Photodyn Ther · vol. 23 · págs. 254–260
- Editorial
- Elsevier BV
- Citado
- 45 citas · más que el 71% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral Health Pathology and Treatment · Oral health in cancer treatment · Laser Applications in Dentistry and Medicine
- Palabras clave
- oral lichen planus, photodynamic therapy, low-level laser therapy, corticosteroid therapy, oral pain, lesion severity, oral lesions, phototherapy
- MeSH
- humans, lichen planus, oral, adrenal cortex hormones, photochemotherapy, clinical trials as topic, low-level light therapy
6 autores
- Hassan Hosseinpour Jajarm🇮🇷Mashhad University of Medical Sciences
- Reza Asadi🇮🇷Mashhad University of Medical Sciences
- Erfan Bardideh🇮🇷Mashhad University of Medical Sciences
- Hooman Shafaee🇮🇷 · autor de correspondenciaMashhad University of Medical Sciences
- Yeganeh Khazaei
- Maryam Emadzadeh🇮🇷Mashhad University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral lichen planus (OLP) is a chronic immune-mediated disorder that inflicts oral mucosa in 0.5-2% of the population. Surgery, photodynamic therapy, laser therapy and most commonly pharmacological therapy (like corticosteroids) has been used for treating OLP. New phototherapy approaches have been shown to have positive effects on treating some oral lesions and the aim of our study was to assess the effects of different phototherapy treatments on OLP.
Methods
We conducted a comprehensive electronic search using the determined search strategy in MEDLINE, EMBASE and CENTRAL electronic databases. A hand search of the reference list of the relevant studies and related systematic reviews was also performed.
Results
For low-level laser therapy, before and after studies showed a significant difference in pain (MD = -4.39, CI = 95% -4.83, -3.96) and sign score (MD = -1.86, CI = 95% -2.53, -1.19) after treatment. The comparison between corticosteroid therapy and LLLT also showed a significant difference in their effects for severity (MD = 0.57, CI = 95% 0.04, 1.09), but no differences in sign (MD = 0.21, CI = 95% -0.83, 1.24)and pain (MD = -0.10, CI = 95% -0.57,0.38) score was found between these two methods. Before and after studies of photodynamic therapy did not reveal any differences in lesion size. (MD = -1.95, CI = 95% -4.39, 0.490).
Conclusion
Low-level laser therapy seems to be a reliable alternative to corticosteroids for treating OLP without the adverse effects associated with the pharmacological method. No conclusive evidence for the effectiveness of photodynamic therapy in treating OLP lesion exists.
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