Association between Blood 25-Hydroxyvitamin D Levels and Survival in Colorectal Cancer Patients: An Updated Systematic Review and Meta-Analysis
Maalmi H, Walter V, Jansen L, Boakye D, Schöttker B, Hoffmeister M, Brenner H
Nutrients · 63 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Empresa
- Klaus Tschira Stiftung
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-07-13 · Nutrients · vol. 10 · número 7 · pág. 896
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 97 citas · más que el 94% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- Meta-analysis, Colorectal cancer, Medicine, Hazard ratio, Internal medicine, Subgroup analysis, Confidence interval, Vitamin D and neurology, Oncology, Sample size determination, Publication bias, Randomized controlled trial, Web of science, Cancer
- MeSH
- humans, colorectal neoplasms, vitamin d deficiency, disease progression, vitamin d, neoplasm staging, disease-free survival, treatment outcome, risk factors, time factors, adult, aged, aged, 80 and over, middle aged, female, male, protective factors
7 autores
- Haïfa Maalmi🇩🇪German Cancer Research Center; Heidelberg University
- Viola Walter🇩🇪German Cancer Research Center; Heidelberg University
- Lina Jansen🇩🇪German Cancer Research Center; Heidelberg University
- Daniel Boakye🇩🇪German Cancer Research Center; Heidelberg University
- Ben Schöttker🇩🇪German Cancer Research Center; Heidelberg University
- Michael Hoffmeister🇩🇪German Cancer Research Center; Heidelberg University
- Hermann Brenner🇩🇪 · autor de correspondenciaGerman Cancer Research Center; Heidelberg University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous meta-analyses have shown an improved survival with higher blood 25-hydroxyvitamin D (25(OH)D) concentrations in patients with colorectal cancer (CRC). However, a number of much larger studies have been published since then. We provide an updated meta-analysis to synthesize current evidence. PubMed and Web of Science databases were systematically searched for eligible studies. The dose-response relationships and pooled hazard ratios for overall and CRC-specific survival comparing the highest versus the lowest categories of blood 25(OH)D concentrations were assessed. Subgroup analyses based on study geographic location, year of publication, sample size, length of follow-up time and stage were conducted to explore potential sources of heterogeneity. Overall, 11 original studies with a total of 7718 CRC patients were included. The dose-response meta-analysis showed an improvement in survival outcomes with increasing blood 25(OH)D concentrations. Pooled hazard ratios (95% confidence intervals) comparing highest versus lowest categories were 0.68 (0.55⁻0.85) and 0.67 (0.57⁻0.78) for overall and CRC-specific survival, respectively. Associations were more prominent among studies conducted in Europe, with larger sample sizes, and including stage I⁻IV patients. This updated meta-analysis reveals robust evidence of an association between higher blood 25(OH)D concentrations and better survival in CRC patients. The potential for enhancing prognosis of CRC patients by vitamin D supplementation should be explored by randomized trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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