Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study
Bensalem J, Dudonné S, Etchamendy N, Pellay H, Amadieu C, Gaudout D, Dubreuil S, Paradis ME, Pomerleau S, Capuron L, Hudon C, Layé S, Desjardins Y, Pallet V
The journals of gerontology. Series A, Biological sciences and medical sciences · 80 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Bpifrance
- Gobierno
- Fonds Unique Interministériel
- Gobierno
- Conseil Régional Aquitaine
- Gobierno
- European Regional Development Fund
Según 4 financiadores declarados.
Publicación
- Publicado
- 2018-07-19 · J Gerontol A Biol Sci Med Sci · vol. 74 · número 7 · págs. 996–1007
- Editorial
- Oxford University Press
- Citado
- 125 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Neurological Disease Mechanisms and Treatments · Phytochemicals and Antioxidant Activities · Medicinal Plants and Neuroprotection
- Palabras clave
- Placebo, Double blind, Episodic memory, Medicine, Randomized controlled trial, Psychology, Cognition, Psychiatry, Internal medicine, Alternative medicine
- MeSH
- humans, vitis, presbycusis, flavonoids, plant extracts, treatment outcome, neuropsychological tests, aging, dietary supplements, aged, middle aged, female, male, polyphenols, memory, episodic, spatial navigation, blueberry plants, recognition, psychology
14 autores
- Julien Bensalem🇫🇷Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Complexité, Innovation et Activités Motrices et Sportives; NutriNeuro; Activ'Inside (France)
- Stéphanie Dudonné🇫🇷🇨🇦NutriNeuro; Université Laval
- Nicole Etchamendy🇫🇷Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro
- Hermine Pellay🇫🇷Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Complexité, Innovation et Activités Motrices et Sportives; NutriNeuro; Activ'Inside (France)
- Camille Amadieu🇫🇷Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro
- David Gaudout🇫🇷Complexité, Innovation et Activités Motrices et Sportives; Activ'Inside (France)
- Séverine Dubreuil🇫🇷Complexité, Innovation et Activités Motrices et Sportives; Activ'Inside (France)
- Marie‐Ève Paradis🇫🇷🇨🇦NutriNeuro; Université Laval
- Sonia Pomerleau🇨🇦Université Laval
- Lucile Capuron🇫🇷Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro
- Carol Hudon🇨🇦Institut Universitaire en Santé Mentale de Québec; Université Laval
- Sophie Layé🇫🇷Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro
- Yves Desjardins🇫🇷🇨🇦NutriNeuro; Université Laval
- Véronique Pallet🇫🇷 · autor de correspondenciaInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro; Institut Polytechnique de Bordeaux
Resumen
El texto original del estudio, en el idioma en que se publicó.
Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. This study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary outcome was the CANTAB Paired Associate Learning (PAL), a visuospatial learning and episodic memory test. Secondary outcomes included verbal episodic and recognition memory (VRM) and working memory (SSP). There was no significant effect of PEGB on the PAL on the whole cohort. Yet, PEGB supplementation improved VRM-free recall. Stratifying the cohort in quartiles based on PAL at baseline revealed a subgroup with advanced cognitive decline (decliners) who responded positively to the PEGB. In this group, PEGB consumption was also associated with a better VRM-delayed recognition. In addition to a lower polyphenol consumption, the urine metabolomic profile of decliners revealed that they excreted more metabolites. Urinary concentrations of specific flavan-3-ols metabolites were associated, at the end of the intervention, with the memory improvements. Our study demonstrates that PEGB improves age-related episodic memory decline in individuals with the highest cognitive impairments.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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