Effect of a daily snack containing green leafy vegetables on women's fatty acid status: a randomized controlled trial in Mumbai, India
Chopra HV, Kehoe SH, Sahariah SA, Sane HN, Cox VA, Tarwade DV, Margetts BM, Potdar RD, Fall CH, Joshi SR
Asia Pacific journal of clinical nutrition · 3 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- Department for International Development
- Gobierno
- Medical Research Council
- Subvenciones
- Medical Research Council (U1475000003); Wellcome Trust (098575); Medical Research Council (G0400519); Wellcome Trust (074048)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-09-09 · Asia Pac J Clin Nutr · vol. 27 · número 4 · págs. 804–817
- Editorial
- National Institutes of Health
- Citado
- 5 citas · más que el 54% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Palabras clave
- Malondialdehyde, Polyunsaturated fatty acid, Fatty acid, Medicine, Food science, Glutathione peroxidase, Antioxidant, Superoxide dismutase, Chemistry, Biochemistry
- MeSH
- erythrocytes, humans, vegetables, fatty acids, homocysteine, diet, adolescent, adult, india, female, young adult, snacks
10 autores
- Harsha Chopra🇮🇳Social Change and Development
- Sarah Helen Kehoe🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Sirazul Ameen Sahariah🇮🇳Social Change and Development
- Harshad Sane🇮🇳Social Change and Development
- Vanessa Cox🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Dnyaneshwar V Tarwade🇮🇳Narayana Nethralaya
- Barrie Margetts🇬🇧University of Southampton
- Ramesh D. Potdar🇮🇳Social Change and Development
- Caroline H. D. Fall🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Sadhana Joshi🇮🇳Bharati Vidyapeeth (Deemed to be University)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
There are few data on the fatty acid status of non-pregnant Indian women. Our objective was to investigate the effect of a snack containing green leafy vegetables (GLVs) on women's erythrocyte long chain polyunsaturated fatty acid status (LCPUFA).
Methods and study design
Non-pregnant women (n=222) aged 14-35 years from Mumbai slums were randomized to consume a snack containing GLVs, fruit and milk (treatment) or a control snack containing foods of low micronutrient content such as potato and onion, daily under observation. One treatment snack contained a mean (SD) of 54.1 (33.7) mg alpha-linolenic acid (ALA) and one control snack contained 4.1 (3.4) mg ALA. Blood was collected at baseline (0 weeks) and after 12 weeks of supplementation. Erythrocyte fatty acids were analyzed using gas chromatography and expressed as g/100g fatty acids. Plasma malondialdehyde, homocysteine, and erythrocyte superoxide dismutase and glutathione peroxidase were measured. The effect of the treatment on 12 week LCPUFA was assessed using ANCOVA models.
Results
Median (IQR) erythrocyte DHA in the treatment group increased from 1.50 (1.11, 2.03) at baseline to 1.86 (1.50, 2.43) (p<0.001) at 12 weeks, and fell in controls from 1.78 (1.37, 2.32) to 1.60 (1.32, 2.04) (p<0.001). The total n-3 fatty acids increased in the treatment group. There was no effect on malondialdehyde and antioxidant enzyme levels. Plasma homocysteine at 0 and 12 weeks was inversely associated with erythrocyte DHA at 12 weeks.
Conclusion
Daily consumption of a snack containing GLV improved women's erythrocyte DHA levels without increasing oxidative stress.
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