Financiado en parte por Abbott Laboratories, Pfizer, PepsiCo, Kellogg's, Coca-Cola Foundation, California Strawberry Commission, Danone, Almond Board of California, Dairy Farmers of Canada, Royal Bank of Canada, Saskatchewan Pulse Growers, Canola Council of Canada, Loblaw Companies Limited, California Walnut Commission, Alpro Foundation, International Nut and Dried Fruit Council, DSM, DSM Company, Dow Agrosciences and Flax Council of Canada
Diets Low in Saturated Fat with Different Unsaturated Fatty Acid Profiles Similarly Increase Serum-Mediated Cholesterol Efflux from THP-1 Macrophages in a Population with or at Risk for Metabolic Syndrome: The Canola Oil Multicenter Intervention Trial
Liu X, Garban J, Jones PJ, Vanden Heuvel J, Lamarche B, Jenkins DJ, Connelly PW, Couture P, Pu S, Fleming JA, West SG, Kris-Etherton PM
The Journal of nutrition · 18 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Empresa
- Abbott Laboratories
- Empresa
- Pfizer
- Empresa
- PepsiCo
- Empresa
- Kellogg's
- Empresa
- Coca-Cola Foundation
- Grupo de la industria
- California Strawberry Commission
- Organización sin fines de lucro
- Canadian Diabetes Association
- Universidad u hospital
- Arizona State University
- Empresa
- Danone
- Grupo de la industria
- Almond Board of California
- Grupo de la industria
- Advanced Foods and Materials Network
- Grupo de la industria
- Dairy Farmers of Canada
- Empresa
- Royal Bank of Canada
- Grupo de la industria
- Saskatchewan Pulse Growers
- Organización sin fines de lucro
- Canadian Nutrition Society
- Grupo de la industria
- Canola Council of Canada
- Empresa
- Loblaw Companies Limited
- Organización sin fines de lucro
- Danish Cancer Society Research Center
- Gobierno
- Australian Government
- Grupo de la industria
- California Walnut Commission
- Gobierno
- Government of Canada
- Universidad u hospital
- Hospital for Sick Children
- Empresa
- Alpro Foundation
- Grupo de la industria
- International Nut and Dried Fruit Council
- Organización sin fines de lucro
- Canadian Society of Endocrinology and Metabolism
- Empresa
- DSM
- Gobierno
- National Institutes of Health
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Agriculture and Agri-Food Canada
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Universidad u hospital
- Institute of Nutrition, Metabolism and Diabetes
- Gobierno
- NIH
- Gobierno
- Agriculture and Agri Food Canada
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCATS NIH HHS
- Empresa
- DSM Company
- Grupo de la industria
- Dow Agrosciences and Flax Council of Canada
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (T-32 DK 007703); National Center for Advancing Translational Sciences (UL1-TR000127); National Center for Advancing Translational Sciences (TR000127); National Center for Research Resources (UL1 RR033184); National Institutes of Health (1ul1rr033184-01); National Center for Research Resources (UL1 TR000127); National Center for Research Resources (RR033184); National Center for Advancing Translational Sciences (RR033184); National Institutes of Health (TR000127); National Institutes of Health (UL1-TR-000127); National Institutes of Health (2T32DK007703)
Según 41 financiadores declarados.
Publicación
- Publicado
- 2018-05-01 · J Nutr · vol. 148 · número 5 · págs. 721–728
- Editorial
- Elsevier BV
- Citado
- 25 citas · más que el 85% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- cholesterol efflux capacity, serum cholesterol, THP-1 macrophages, unsaturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, metabolic syndrome, abdominal obesity, abdominal fat, canola oil, corn oil, safflower oil, linseed oil, atherosclerosis
- MeSH
- humans, cholesterol, lipids, dietary fats, unsaturated, lipoproteins, diet, cross-over studies, middle aged, female, male, thp-1 cells, metabolic syndrome, rapeseed oil
12 autores
- Xiaoran Liu🇺🇸Pennsylvania State University
- Josephine Garban🇺🇸Pennsylvania State University
- Peter J.H. Jones🇨🇦University of Manitoba
- Jack Vanden Heuvel🇺🇸Pennsylvania State University
- Benoı̂t Lamarche🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- David J.A. Jenkins🇨🇦St. Michael's Hospital; University of Toronto
- Philip W. Connelly🇨🇦St. Michael's Hospital
- Patrick Couture🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Shuaihua Pu🇺🇸Pennsylvania State University
- Jennifer A Fleming🇺🇸Pennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
- Penny M. Kris‐Etherton🇺🇸 · autor de correspondenciaPennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cholesterol efflux plays an important role in preventing atherosclerosis progression. Vegetable oils with varying unsaturated fatty acid profiles favorably affect multiple cardiovascular disease risk factors; however, their effects on cholesterol efflux remain unclear.
Objective
The objectives of this study were to examine the effects of diets low in saturated fatty acids (SFAs) with varying unsaturated fatty acid profiles on serum-mediated cholesterol efflux and its association with the plasma lipophilic index and central obesity.
Methods
The present study is a randomized, crossover, controlled-feeding study. Participants [men: n = 50; women: n = 51; mean ± SE age: 49.5 ± 1.2 y; body mass index (in kg/m2): 29.4 ± 0.4] at risk for or with metabolic syndrome (MetS) were randomly assigned to 5 isocaloric diets containing the treatment oils: canola oil, high oleic acid-canola oil, DHA-enriched high oleic acid-canola oil, corn oil and safflower oil blend, and flax oil and safflower oil blend. These treatment oils were incorporated into smoothies that participants consumed 2 times/d. For a 3000-kcal diet, 60 g of treatment oil was required to provide 18% of total energy per day. Each diet period was 4 wk followed by a 2- to 4-wk washout period. We quantified cholesterol efflux capacity with a validated ex vivo high-throughput cholesterol efflux assay. Statistical analyses were performed with the use of the SAS mixed-model procedure.
Results
The 5 diets increased serum-mediated cholesterol efflux capacity from THP-1 macrophages similarly by 39%, 34%, 55%, 49% and 51%, respectively, compared with baseline (P < 0.05 for all). Waist circumference and abdominal adiposity were negatively correlated with serum-mediated cholesterol efflux capacity (r = -0.25, P = 0.01, r = -0.33, P = 0.02, respectively).
Conclusion
Diets low in SFAs with different monounsaturated fatty acid and polyunsaturated fatty acid profiles improved serum-mediated cholesterol efflux capacity in individuals with or at risk for MetS. This mechanism may account, in part, for the cardiovascular disease benefits of diets low in SFAs and high in unsaturated fatty acids. Importantly, central obesity is inversely associated with cholesterol efflux capacity. This trial was registered at www.clinicaltrials.gov as NCT01351012.
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