Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
Ryszewska-Pokraśniewicz B, Mach A, Skalski M, Januszko P, Wawrzyniak ZM, Poleszak E, Nowak G, Pilc A, Radziwoń-Zaleska M
Nutrients · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Warszawski Uniwersytet Medyczny
- Gobierno
- Narodowe Centrum Nauki
- Universidad u hospital
- Uniwersytet Warszawski
- Gobierno
- National Science Center [Narodowe Centrum Nauki]
- Universidad u hospital
- Medical University of Warsaw and Institute of Pharmacology PAS, Kraków.
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-08-03 · Nutrients · vol. 10 · número 8 · pág. 1014
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 30 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Bipolar Disorder and Treatment · Coordination Chemistry and Organometallics
- Palabras clave
- Fluoxetine, Placebo, Magnesium, Antidepressant, Major depressive disorder, Internal medicine, Medicine, Sertraline, Anesthesia, Pharmacology, Chemistry, Serotonin
- MeSH
- humans, fluoxetine, aspartic acid, antidepressive agents, second-generation, treatment outcome, remission induction, double-blind method, affect, depressive disorder, time factors, dietary supplements, adult, aged, middle aged, poland, female, male, young adult, selective serotonin reuptake inhibitors
9 autores
- Beata Ryszewska-Pokraśniewicz
- Anna Mach🇵🇱 · autor de correspondenciaMedical University of Warsaw
- Michał Skalski🇵🇱Medical University of Warsaw
- Piotr Januszko🇵🇱Medical University of Warsaw
- Zbigniew Maciej Wawrzyniak🇵🇱Warsaw University of Technology
- Ewa Poleszak🇵🇱Medical University of Lublin
- Gabriel Nowak🇵🇱Maj Institute of Pharmacology; Polish Academy of Sciences
- Andrzej Pilc🇵🇱Maj Institute of Pharmacology; Polish Academy of Sciences
- Maria Radziwoń-Zaleska🇵🇱Medical University of Warsaw
Resumen
El texto original del estudio, en el idioma en que se publicó.
Animal studies using tests and models have demonstrated that magnesium exerts an antidepressant effect. The literature contains few studies in humans involving attempts to augment antidepressant therapy with magnesium ions. The purpose of our study was to assess the efficacy and safety of antidepressant treatment, in combination with magnesium ions. A total of 37 participants with recurrent depressive disorder who developed a depressive episode were included in this study. As part of this double-blind study, treatment with the antidepressant fluoxetine was accompanied with either magnesium ions (120 mg/day as magnesium aspartate) or placebo. During an 8-week treatment period, each patient was monitored for any clinical abnormalities. Moreover, serum fluoxetine and magnesium levels were measured, and pharmaco-electroencephalography was performed. The fluoxetine + magnesium and fluoxetine + placebo groups showed no significant differences in either Hamilton Depression Rating Scale (HDRS) scores or serum magnesium levels at any stage of treatment. Multivariate statistical analysis of the whole investigated group showed that the following parameters increased the odds of effective treatment: lower baseline HDRS scores, female gender, smoking, and treatment augmentation with magnesium. The parameters that increased the odds of remission were lower baseline HDRS scores, shorter history of disease, the presence of antidepressant-induced changes in the pharmaco-EEG profile at 6 h after treatment, and the fact of receiving treatment augmented with magnesium ions. The limitation of this study is a small sample size.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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