Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth
Roth DE, Morris SK, Zlotkin S, Gernand AD, Ahmed T, Shanta SS, Papp E, Korsiak J, Shi J, Islam MM, Jahan I, Keya FK, Willan AR, Weksberg R, Mohsin M, Rahman QS, Shah PS, Murphy KE, Stimec J, Pell LG, Qamar H, Al Mahmud A
The New England journal of medicine · 160 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Bill and Melinda Gates Foundation
- Universidad u hospital
- Hospital for Sick Children
- Gobierno
- Ministry of Health and Family Welfare
- Subvenciones
- Bill and Melinda Gates Foundation (OPP1066764)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-08-08 · N Engl J Med · vol. 379 · número 6 · págs. 535–546
- Editorial
- Massachusetts Medical Society
- Citado
- 267 citas · más que el 100% de estudios similares · 18.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Birth, Development, and Health · Gestational Diabetes Research and Management
- Palabras clave
- Medicine, Pregnancy, Prenatal care, Placebo, Anthropometry, Obstetrics, Vitamin D and neurology, Vitamin, Gestation, Lactation, Birth weight, Randomized controlled trial, Pediatrics, Population, Endocrinology, Internal medicine, Biology
- MeSH
- humans, pregnancy complications, fetal growth retardation, vitamin d deficiency, vitamins, vitamin d, body height, prenatal care, double-blind method, growth, postpartum period, lactation, pregnancy, dose-response relationship, drug, developing countries, dietary supplements, adult, infant, infant, newborn, bangladesh, female
22 autores
- Daniel E. Roth🇨🇦University of Toronto; Centre for Global Health Research
- Shaun K. Morris🇨🇦University of Toronto; Centre for Global Health Research
- Stanley Howard Zlotkin🇨🇦University of Toronto; Centre for Global Health Research
- Alison D. Gernand🇺🇸🇧🇩Pennsylvania State University; State University of Bangladesh
- Tahmeed Ahmed🇧🇩International Centre for Diarrhoeal Disease Research
- Shaila Sharmeen Shanta🇧🇩International Centre for Diarrhoeal Disease Research
- Eszter Papp🇨🇦University of Toronto; Centre for Global Health Research
- Jill Korsiak🇨🇦University of Toronto; Centre for Global Health Research
- Joy Shi🇨🇦University of Toronto; Centre for Global Health Research
- M Munirul Islam🇧🇩International Centre for Diarrhoeal Disease Research
- Ishrat Jahan🇧🇩Child Health Research Foundation; Institute of Child and Mother Health
- Farhana Khanam Keya🇧🇩International Centre for Diarrhoeal Disease Research
- Andrew R. Willan🇺🇸🇨🇦🇬🇧3M (United States); University of Toronto; Great Ormond Street Hospital; Hospital for Sick Children; SickKids Foundation; University College London
- Rosanna Weksberg🇨🇦University of Toronto; Centre for Global Health Research
- Minhazul Mohsin🇧🇩International Centre for Diarrhoeal Disease Research
- Qazi Sadeq-ur Rahman🇧🇩International Centre for Diarrhoeal Disease Research
- Prakesh S. Shah🇨🇦🇺🇸University of Toronto; Sinai Hospital
- Kellie E. Murphy🇺🇸Sinai Hospital
- Jennifer Stimec
- Lisa G. Pell🇨🇦University of Toronto; Centre for Global Health Research
- Huma Qamar🇨🇦University of Toronto; Centre for Global Health Research
- Abdullah Al Mahmud🇧🇩International Centre for Diarrhoeal Disease Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
It is unclear whether maternal vitamin D supplementation during pregnancy and lactation improves fetal and infant growth in regions where vitamin D deficiency is common.
Methods
We conducted a randomized, double-blind, placebo-controlled trial in Bangladesh to assess the effects of weekly prenatal vitamin D supplementation (from 17 to 24 weeks of gestation until birth) and postpartum vitamin D supplementation on the primary outcome of infants' length-for-age z scores at 1 year according to World Health Organization (WHO) child growth standards. One group received neither prenatal nor postpartum vitamin D (placebo group). Three groups received prenatal supplementation only, in doses of 4200 IU (prenatal 4200 group), 16,800 IU (prenatal 16,800 group), and 28,000 IU (prenatal 28,000 group). The fifth group received prenatal supplementation as well as 26 weeks of postpartum supplementation in the amount of 28,000 IU (prenatal and postpartum 28,000 group).
Results
Among 1164 infants assessed at 1 year of age (89.5% of 1300 pregnancies), there were no significant differences across groups in the mean (±SD) length-for-age z scores. Scores were as follows: placebo, -0.93±1.05; prenatal 4200, -1.11±1.12; prenatal 16,800, -0.97±0.97; prenatal 28,000, -1.06±1.07; and prenatal and postpartum 28,000, -0.94±1.00 (P=0.23 for a global test of differences across groups). Other anthropometric measures, birth outcomes, and morbidity did not differ significantly across groups. Vitamin D supplementation had expected effects on maternal and infant serum 25-hydroxyvitamin D and calcium concentrations, maternal urinary calcium excretion, and maternal parathyroid hormone concentrations. There were no significant differences in the frequencies of adverse events across groups, with the exception of a higher rate of possible hypercalciuria among the women receiving the highest dose.
Conclusions
In a population with widespread prenatal vitamin D deficiency and fetal and infant growth restriction, maternal vitamin D supplementation from midpregnancy until birth or until 6 months post partum did not improve fetal or infant growth. (Funded by the Bill and Melinda Gates Foundation; ClinicalTrials.gov number, NCT01924013 .).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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