Low linolenic and linoleic acid consumption are associated with chronic kidney disease in patients with type 2 diabetes
Dos Santos ALT, Duarte CK, Santos M, Zoldan M, Almeida JC, Gross JL, Azevedo MJ, Lichtenstein AH, Zelmanovitz T
PloS one · 42 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Organización sin fines de lucro
- Fundação Instituto de Pesquisas Econômicas
- Sin clasificar
- FIPE
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (502050/2005-5); Fundação Instituto de Pesquisas Econômicas (07-612)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-08-09 · PLoS One · vol. 13 · número 8 · pág. e0195249
- Editorial
- Public Library of Science
- Citado
- 57 citas · más que el 92% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Chronic Kidney Disease and Diabetes · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- Medicine, Type 2 diabetes, Diabetes mellitus, Kidney disease, Internal medicine, Renal function, Body mass index, Gastroenterology, Albuminuria, Endocrinology, Blood pressure
- MeSH
- humans, diabetic nephropathies, diabetes mellitus, type 2, dietary fats, alpha-linolenic acid, linoleic acid, diet surveys, risk factors, cross-sectional studies, feeding behavior, aged, middle aged, brazil, female, male, renal insufficiency, chronic
9 autores
- Ana Luiza Teixeira dos Santos🇧🇷Universidade Federal do Rio Grande do Sul
- Camila Kümmel Duarte🇧🇷Universidade Federal do Rio Grande do Sul
- Manoella Freitas Santos🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Maira Zoldan🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Jussara Carnevalle Almeida🇧🇷Universidade Federal do Rio Grande do Sul
- Jorge Luiz Gross🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Mirela Jobim de Azevedo🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Alice Hinda Lichtenstein🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Themis Zelmanovitz🇧🇷 · autor de correspondenciaUniversidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
This cross-sectional study aimed to assess the association of the fat content in the diet with Diabetic Kidney Disease (DKD) in patients with type 2 diabetes.
Methodology
Patients from the Diabetes research clinic at Hospital de Clínicas de Porto Alegre (Brazil) were consecutively recruited. The inclusion criterion was the diagnosis of type 2 diabetes. The exclusion criteria were as follows: body mass index >40 kg/m2, heart failure, gastroparesis, diabetic diarrhea, dietary counseling by a registered dietitian during the previous 12 months, and inability to perform the weighed diet records (WDR). The dietary fatty acids (saturated, monounsaturated and polyunsaturated) consumption was estimated by 3-day WDR. Compliance with the WDR technique was assessed by comparison of protein intake estimated from the 3-day WDR and from the 24-h urinary nitrogen output performed on the third day of the WDR period. The presence of DKD was defined as urinary albumin excretion (UAE) ≥ 30 mg / 24 h or/and glomerular filtration rate (eGFR) <60 ml/min/1.73 m2. Urinary albumin was measured twice and eGFR was estimated by using the CKD-EPI equation.
Results
A total of 366 patients were evaluated; of these, 33% (n = 121) had DKD. Multivariate analysis showed that the intake of linolenic acid was negatively associated with DKD (OR = 0.57; 95% CI 0.35-0.93; P = 0.024), adjusted for gender, smoking, cardiovascular disease, ACE inhibitors and/or angiotensin receptor blocker use, systolic blood pressure, fasting plasma glucose and HDL cholesterol. In a separate model, similar results were observed for linoleic acid, adjusting to the same co-variables (OR = 0.95; 95% CI 0.91-0.99; P = 0.006).
Conclusion
The lower intake of polyunsaturated fatty acids, especially linolenic and linoleic acid, is associated with chronic kidney disease in patients with type 2 diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.