Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial
Ormesher L, Myers JE, Chmiel C, Wareing M, Greenwood SL, Tropea T, Lundberg JO, Weitzberg E, Nihlen C, Sibley CP, Johnstone ED, Cottrell EC
Nitric oxide : biology and chemistry · 55 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- NIHR Clinician Scientist Fellowship
- Organización sin fines de lucro
- British Heart Foundation Fellowship Grant
- Universidad u hospital
- Tommy's Maternal and Fetal Health Research Centre
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- British Heart Foundation (FS/15/31/31418); National Institute for Health and Care Research (NIHR-CS-011-020)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2018-08-09 · Nitric Oxide · vol. 80 · págs. 37–44
- Editorial
- Elsevier BV
- Citado
- 75 citas · más que el 97% de estudios similares · 6.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Pregnancy and preeclampsia studies · Nitric Oxide and Endothelin Effects · Blood Pressure and Hypertension Studies
- Palabras clave
- dietary nitrate, beetroot juice, hypertension in pregnancy, blood pressure, nitrite, plasma nitrate, salivary nitrate, uteroplacental blood flow, oral microbiota, treatment acceptability, preeclampsia
- MeSH
- humans, beta vulgaris, hypertension, pregnancy-induced, nitrates, antihypertensive agents, placebos, treatment outcome, double-blind method, pregnancy, blood pressure, dietary supplements, adult, infant, newborn, female, fruit and vegetable juices
12 autores
- Laura Ormesher🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Jenny Myers🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Catherine Chmiel🇬🇧Manchester Academic Health Science Centre; St Mary's Hospital; Manchester University NHS Foundation Trust
- Mark Wareing🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Susan L. Greenwood🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Teresa Tropea🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Jon O. Lundberg🇸🇪Karolinska Institutet
- Eddie Weitzberg🇸🇪Karolinska Institutet
- Carina Nihlén🇸🇪Karolinska Institutet
- Colin Peter Sibley🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Edward Johnstone🇬🇧Manchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
- Elizabeth C. Cottrell🇬🇧 · autor de correspondenciaManchester Academic Health Science Centre; University of Manchester; St Mary's Hospital; Manchester University NHS Foundation Trust
Resumen
El texto original del estudio, en el idioma en que se publicó.
Chronic hypertension in pregnancy is associated with significant adverse pregnancy outcomes, increasing the risk of pre-eclampsia, fetal growth restriction and preterm birth. Dietary nitrate, abundant in green leafy vegetables and beetroot, is reduced in vivo to nitrite and subsequently nitric oxide, and has been demonstrated to lower blood pressure, improve vascular compliance and enhance blood flow in non-pregnant humans and animals. The primary aims of this study were to determine the acceptability and efficacy of dietary nitrate supplementation, in the form of beetroot juice, to lower blood pressure in hypertensive pregnant women. In this double-blind, placebo-controlled feasibility trial, 40 pregnant women received either daily nitrate supplementation (70 mL beetroot juice, n = 20) or placebo (70 mL nitrate-depleted beetroot juice, n = 20) for 8 days. Blood pressure, cardiovascular function and uteroplacental blood flow was assessed at baseline and following acute (3 h) and prolonged (8 days) supplementation. Plasma and salivary samples were collected for analysis of nitrate and nitrite concentrations and acceptability of this dietary intervention was assessed based on questionnaire feedback. Dietary nitrate significantly increased plasma and salivary nitrate/nitrite concentrations compared with placebo juice (p < 0.001), with marked variation between women. Compared with placebo, there was no overall reduction in blood pressure in the nitrate-treated group; however there was a highly significant correlation between changes in plasma nitrite concentrations and changes in diastolic blood pressure in the nitrate-treated arm only (r = -0.6481; p = 0.0042). Beetroot juice supplementation was an acceptable dietary intervention to 97% of women. This trial confirms acceptability and potential efficacy of dietary nitrate supplementation in pregnant women. Conversion of nitrate to nitrite critically involves oral bacterial nitrate reductase activities. We speculate that differences in efficacy of nitrate supplementation relate to differences in the oral microbiome, which will be investigated in future studies.
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