Financiado en parte por Discovery Foundation, Thermo-Fisher South Africa, Nestlé Nutrition Institute Africa
Predictive values of alpha-gal IgE levels and alpha-gal IgE: Total IgE ratio and oral food challenge-proven meat allergy in a population with a high prevalence of reported red meat allergy
Mabelane T, Basera W, Botha M, Thomas HF, Ramjith J, Levin ME
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 99 citas
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Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- Discovery Eye Foundation
- Universidad u hospital
- Department of Paediatrics, University of Melbourne
- Organización sin fines de lucro
- Allergy Society of South Africa
- Empresa
- Discovery Foundation
- Empresa
- Thermo-Fisher South Africa
- Universidad u hospital
- Department of Paediatrics
- Empresa
- Nestlé Nutrition Institute Africa
Según 7 financiadores declarados.
Publicación
- Publicado
- 2018-08-24 · Pediatr Allergy Immunol · vol. 29 · número 8 · págs. 841–849
- Editorial
- Wiley
- Citado
- 129 citas · más que el 98% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food Allergy and Anaphylaxis Research · Allergic Rhinitis and Sensitization · Contact Dermatitis and Allergies
- Palabras clave
- Medicine, Immunoglobulin E, Allergy, Food allergy, Sensitization, Oral food challenge, Population, Immunology, Red meat, Anaphylaxis, Antibody, Pathology, Environmental health
- MeSH
- humans, food hypersensitivity, disaccharides, immunoglobulin e, allergens, immunologic tests, prevalence, sensitivity and specificity, cross-sectional studies, phenotype, meat, adolescent, adult, aged, middle aged, child, female, male, young adult, surveys and questionnaires
6 autores
- Tshegofatso Mabelane🇿🇦University of Cape Town
- Wisdom Basera🇿🇦Western Cape Department of Health; University of Cape Town
- Maresa Botha🇿🇦University of Cape Town
- Heidi Facey Thomas🇿🇦University of Cape Town
- Jordache Ramjith🇳🇱🇿🇦Radboud University Nijmegen; University of Cape Town; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Michael Eliad Levin🇿🇦🇬🇧 · autor de correspondenciaUniversity of Cape Town; Worldwide Universities Network
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Severe meat allergy with anaphylaxis may be caused by sensitization to alpha-gal. Levels of alpha-gal sensitization that correlate with high risk of meat allergy are currently unknown. We have identified an area with a high prevalence of reported red meat allergy which offered the opportunity to evaluate the diagnostic value of IgE antibody tests.
Methods
To determine levels of alpha-gal IgE and alpha-gal:total IgE ratio in a large cohort of subjects with challenge-proven meat allergy compared with control subjects from the same environment, we conducted fieldwork assessing 131 participants who reported adverse reactions to meat, and 26 control subjects, by questionnaires, IgE sensitization to alpha-gal and oral food challenge to beef sausage.
Results
Eighty-four participants were diagnosed with alpha-gal allergy. Alpha-gal IgE ranged between 0.7 and 344.5 kU/L. Alpha-gal:total IgE ratio ranged from 0.1% to 67.6%. Logistic regression analysis showed both alpha-gal IgE and alpha-gal:total IgE ratio strongly correlated with meat allergy, with AUC of 0.95. The values giving the best correct classification were IgE of 2.00 kU/L and ratio of 0.75%. The value above which there is a 95% probability of meat allergy is IgE>5.5 kU/L and ratio of 2.12%.
Conclusion
Alpha-gal allergy in a population with a high prevalence of reported red meat allergy showed a more rapid onset of symptoms than previously described and a high prevalence of isolated subjective gastrointestinal manifestations. Cutoff values are described for levels of sensitization to alpha-gal IgE and alpha-gal:total IgE ratio that are highly likely to result in clinically significant meat allergy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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