Association Between Magnesium Status, Dietary Magnesium Intake, and Metabolic Control in Patients with Type 2 Diabetes Mellitus
Ozcaliskan Ilkay H, Sahin H, Tanriverdi F, Samur G
Journal of the American College of Nutrition · 21 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-08-30 · J Am Coll Nutr · vol. 38 · número 1 · págs. 31–39
- Editorial
- Taylor & Francis
- Citado
- 33 citas · más que el 80% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Biomarkers in Disease Mechanisms
- Palabras clave
- Hypomagnesemia, Internal medicine, Postprandial, Medicine, Endocrinology, Glycemic, Magnesium, Magnesium deficiency (plants), Diabetes mellitus, Type 2 Diabetes Mellitus, Insulin, Metabolic control analysis, Insulin resistance, Chemistry
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, magnesium deficiency, magnesium, blood glucose, diet, cross-sectional studies, body composition, nutritional status, middle aged, female, male, surveys and questionnaires, glycated hemoglobin
4 autores
- H. Ozcaliskan Ilkay🇹🇷 · autor de correspondenciaErciyes University
- Habibe Şahin🇹🇷Erciyes University
- Fatih Tanrıverdi🇹🇷Erciyes University
- Gülhan Samur🇹🇷Hacettepe University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Hypomagnesemia could worsen glycemic control by impairing insulin release and promoting insulin resistance. On the contrary, type 2 diabetes mellitus (T2DM) may induce and/or exacerbate low serum magnesium levels, and this could, in turn, worsen glycemic control of diabetes.
Objective
The aim of this study was to investigate the relationship between serum magnesium level, dietary magnesium intake, and metabolic control parameters in patients with T2DM.
Methods
The study included 119 patients with T2DM (26 male, 93 female; mean age 54.7 ± 8.4 years). Serum magnesium level was measured by spectrophotometric method. Magnesium intake was assessed by food frequency questionnaire. Anthropometric measurements were taken. The General Linear Model procedure was applied to determine the relationship of serum magnesium with quantitative variables.
Results
Of the 119 patients, 23.5% of the patients had inadequate magnesium intake (lower than 67% of the recommended daily allowance), and 18.5% had hypomagnesemia. In patients with hypomagnesemia (< 0.75 mmol/l), serum levels of fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and serum glycosylated hemoglobin (HbA1c) were higher compared to patients with normomagnesemia. FPG levels were significantly higher in patients with hypomagnesemia in Model 1 (179.0 ± 64.9 vs. 148.7 ± 52.0 mg/dl, p = 0.009) but the significance disappeared in other models. PPG levels were significantly higher in patients with hypomagnesemia in all models (287.9 ± 108.4 vs. 226.8 ± 89.4 mg/dl, p = 0.006 for Model 1, p = 0.027 for Model 2, p = 0.016 for Model 3). Serum HbA1c levels were significantly higher in patients with hypomagnesemia, and this significance proceeded (8.0 ± 1.9% vs. 6.5 ± 1.2%, p = 0.000 for all models). Body fat mass was significantly higher in patients with hypomagnesemia as compared to patients with normomagnesemia in model 3 (35.4 ± 9.4 kg, 34.6 ± 10.2 kg; p = 0.034). Dietary magnesium intake was not significantly associated with either metabolic parameters or anthropometric measurements.
Conclusion
Hypomagnesemia in T2DM is directly associated with poor metabolic control. Clinical assessment should, therefore, focus on augmentation of magnesium status and adequate magnesium intake in patients with T2DM.
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