Olive oil lessened fatty liver severity independent of cardiometabolic correction in patients with non-alcoholic fatty liver disease: A randomized clinical trial
Rezaei S, Akhlaghi M, Sasani MR, Barati Boldaji R
Nutrition (Burbank, Los Angeles County, Calif.) · 50 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shiraz University of Medical Sciences
- Subvenciones
- Shiraz University of Medical Sciences (94-01-87-9914)
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-03-23 · Nutrition · vol. 57 · págs. 154–161
- Editorial
- Elsevier BV
- Citado
- 75 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Edible Oils Quality and Analysis
- Palabras clave
- olive oil, sunflower oil, non-alcoholic fatty liver disease, cardiometabolic risk factors, hypocaloric diet, dietary fat, skeletal muscle mass, body fat percentage, liver enzymes, malondialdehyde, interleukin-6, obesity
- MeSH
- muscle, skeletal, liver, adipose tissue, humans, olea, cardiovascular diseases, obesity, alanine transaminase, aspartate aminotransferases, dietary fats, triglycerides, caloric restriction, diet, reducing, severity of illness index, risk factors, double-blind method, blood pressure, adult, middle aged, female, male, waist circumference, non-alcoholic fatty liver disease, olive oil
4 autores
- Shahla Rezaei🇮🇷Shiraz University of Medical Sciences
- Masoumeh Akhlaghi🇮🇷 · autor de correspondenciaShiraz University of Medical Sciences
- Mohammad Reza Sasani🇮🇷Shiraz University of Medical Sciences
- Reza Barati‐Boldaji🇮🇷Shiraz University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Olive oil has health benefits for the correction of metabolic diseases. We aimed to evaluate the effect of olive oil consumption on the severity of fatty liver and cardiometabolic markers in patients with non-alcoholic fatty liver disease.
Methods
This randomized, double-blind, clinical trial was conducted on 66 patients with non-alcoholic fatty liver disease. Patients were divided to receive either olive or sunflower oil, each 20 g/d for 12 wk. A hypocaloric diet (-500 kcal/d) was recommended to all participants. Fatty liver grade, liver enzymes, anthropometric parameters, blood pressure, serum lipid profile, glucose, insulin, malondialdehyde, total antioxidant capacity, and interleukin-6 were assessed pre- and postintervention.
Results
Fatty liver grade, weight, waist circumference, and blood pressure significantly decreased in both groups. Sunflower oil significantly reduced serum aspartate and alanine aminotransferases and olive oil only decreased serum aspartate aminotransferase. Fat-free mass and skeletal muscle mass significantly reduced after the consumption of sunflower oil and serum triacylglycerols and fat mass significantly declined after the ingestion of olive oil. Among these variables, only changes in fatty liver grade (-0.29 ± 0.46 in sunflower oil versus -0.75 ± 0.45 in olive oil; P < 0.001), skeletal muscle mass (-0.71 ± 1.36 in sunflower oil versus +0.45 ± 2.8 in olive oil; P = 0.04), and body fat percentage (+0.38 ± 5.2% in sunflower oil versus -3.4 ± 5.5% in olive oil; P = 0.04) were significantly different between the groups.
Conclusions
Olive oil may alleviate the severity of fatty liver independent of correcting cardiometabolic risk factors. Low-calorie diets may benefit patients with non-alcoholic fatty liver disease additionally through mitigation of obesity, blood pressure, and liver enzymes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.