Financiado en parte por Scharper S.p.A
Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy
De Benedetto F, Pastorelli R, Ferrario M, de Blasio F, Marinari S, Brunelli L, Wouters EFM, Polverino F, Celli BR, Interdisciplinary Association for Research in Lung Disease (AIMAR) Study Group
Respiratory medicine · 36 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Scharper S.p.A
- Organización sin fines de lucro
- Interdisciplinary Association for Research in Lung Disease
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-08-07 · Respir Med · vol. 142 · págs. 86–93
- Editorial
- Elsevier BV
- Citado
- 44 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 96 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Coenzyme Q10 studies and effects · Nutrition and Health in Aging
- Palabras clave
- chronic obstructive pulmonary disease, long-term oxygen therapy, coenzyme Q10, creatine supplementation, nutraceuticals, functional capacity, 6-minute walk test, body composition, dyspnea, oxidative stress, mitochondrial function, metabolomics, activities of daily living, BODE index
- MeSH
- humans, pulmonary disease, chronic obstructive, creatine, ubiquinone, antioxidants, activities of daily living, oxygen inhalation therapy, double-blind method, body composition, time factors, dietary supplements, aged, aged, 80 and over, middle aged, female, male, walk test, physical functional performance
9 autores
- Fernando De Benedetto🇮🇹Ospedale SS. Annunziata
- Roberta Pastorelli🇮🇹Mario Negri Institute for Pharmacological Research
- Manuela Ferrario🇮🇹Politecnico di Milano
- Francesca de Blasio🇮🇹 · autor de correspondenciaUniversity of Turin
- Stefano Marinari🇮🇹Ospedale SS. Annunziata
- Laura Brunelli🇮🇹Mario Negri Institute for Pharmacological Research
- Emiel F.�M. Wouters🇳🇱Maastricht University Medical Centre; Maastricht University
- Francesca Polverino🇺🇸University of Arizona
- Bartolomé R. Celli🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer®) - a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function - and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O2 therapy.
Methods
One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured.
Findings
Ninety patients, who randomly received supplementation with QTer® and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 ± 69 versus 15 ± 91 m, p < 0.05), body cell mass and phase angle, sodium/potassium ratio, dyspnea indices and ADL score. The CoQ10 plasma concentration increased in the supplementation group whereas it did not change in the placebo group. The metabolomics profile also differed between groups. Adverse events were similar in both groups.
Interpretation
These results show that in patients with COPD, dietary supplementation with CoQ10 and Creatine improves functional performance, body composition and perception of dyspnea. A systemic increase in some anti-inflammatory metabolites supports a pathobiological mechanism as a reason for these benefits. Further trials should help clarifying the role of QTer® and Creatine supplementation in patients with COPD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.