Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis
Ju SY, Lee JY, Kim DH
BMC geriatrics · 57 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Catholic University of Korea
- Universidad u hospital
- College of Medicine, Catholic University of Korea
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-09-04 · BMC Geriatr · vol. 18 · número 1 · pág. 206
- Editorial
- BioMed Central
- Citado
- 84 citas · más que el 85% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Gut microbiota and health · HIV-related health complications and treatments
- Palabras clave
- Medicine, Meta-analysis, Vitamin D and neurology, Akaike information criterion, Internal medicine, vitamin D deficiency, Confidence interval, Cohort study, Prospective cohort study, Cochrane Library, Relative risk, Frailty syndrome, Cohort, Statistics
- MeSH
- humans, vitamin d, geriatric assessment, incidence, aged, frail elderly, global health, frailty
3 autores
- Sang-Yhun Ju🇰🇷 · autor de correspondenciaThe Catholic University of Korea Yeouido St. Mary's Hospital; Catholic University of Korea
- Juneyoung Lee🇰🇷Korea University
- Do‐Hoon Kim🇰🇷Korea University; Ansan University; Korea University Ansan Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D deficiency and frailty are common with aging. Previous studies examining vitamin D status and frailty have produced mixed results, and in particular, the shape of the association has not been well established. We examined the association between 25-hydroxyvitamin D (25OHD) serum levels and frailty by performing a systematic review and dose-response meta-analysis.
Methods
We searched the PubMed, EMBASE and Cochrane Library databases of Elsevier through February 2017. Cross-sectional and cohort studies that reported adjusted risk ratios with 95% confidence intervals (CI) for frailty with ≥3 categories of 25OHD serum levels were selected. Data extraction was performed independently by two authors. The reported risk estimates for 25OHD categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data.
Results
The pooled risk estimate of frailty syndrome per 25 nmol/L increment in serum 25OHD concentration was 0.88 (95% CI = 0.82-0.95, I2 = 86.8%) in the 6 cross-sectional studies and 0.89 (95% CI = 0.85-0.94, I2 = 0.0%) in the 4 prospective cohort studies. Based on the Akaike information criteria (AIC), a linear model was selected (AIC for the nonlinear model: - 5.4, AIC for the linear model: - 6.8 in the prospective cohort studies; AIC for the linear model: - 13.6, AIC for the nonlinear model: - 1.77 in the cross-sectional studies).
Conclusions
This dose-response meta-analysis indicates that serum 25OHD levels are significantly and directly associated with the risk of frailty. Further studies should address the underlying mechanisms to explain this relationship and to determine whether vitamin D supplementation is effective for preventing frailty syndrome.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.