Financiado en parte por H. Lundbeck A/S
Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial
Vinding RK, Stokholm J, Sevelsted A, Sejersen T, Chawes BL, Bønnelykke K, Thorsen J, Howe LD, Krakauer M, Bisgaard H
BMJ (Clinical research ed.) · 34 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Strategiske Forskningsråd
- Universidad u hospital
- University of Bristol
- Organización sin fines de lucro
- Lundbeckfonden
- Empresa
- H. Lundbeck A/S
- Gobierno
- Medical Research Council
- Subvenciones
- Strategiske Forskningsråd (0603–00280B); Medical Research Council (MC_UU_12013_5); Lundbeckfonden (R16‐A1694); Medical Research Council (MC_UU_12013); Medical Research Council (MR/M020894); Medical Research Council (MR/M020894/1); University of Bristol (MC_UU_12013/5); Medical Research Council (MR/M020894/1)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2018-09-04 · BMJ · vol. 362 · pág. k3312
- Citado
- 57 citas · más que el 97% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Gestational Diabetes Research and Management
- Palabras clave
- Fish oil, Pregnancy, Medicine, Lean body mass, Fish <Actinopterygii>, Clinical trial, Fish bone, Randomized controlled trial, Obstetrics, Internal medicine, Biology, Body weight, Fishery
- MeSH
- humans, prenatal exposure delayed effects, fatty acids, omega-3, fish oils, absorptiometry, photon, body mass index, prenatal care, prospective studies, double-blind method, bone development, pregnancy, bone density, dietary supplements, adult, child, infant, female, infant nutritional physiological phenomena, maternal nutritional physiological phenomena
10 autores
- Rebecca Vinding🇩🇰University of Copenhagen; Gentofte Hospital; Næstved Sygehus; Copenhagen Prospective Studies on Asthma in Childhood
- Jakob Stokholm🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Astrid Sevelsted🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Tobias Steen Sejersen🇩🇰University of Copenhagen; Gentofte Hospital; Næstved Sygehus; Copenhagen Prospective Studies on Asthma in Childhood
- Bo Chawes🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Klaus Bønnelykke🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Jonathan Thorsen🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Laura D Howe🇬🇧University of Bristol
- Martin Krakauer🇩🇰Gentofte Hospital
- Hans Bisgaard🇩🇰 · autor de correspondenciaUniversity of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the effect of supplementation with n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) in pregnancy on anthropometry and body composition in offspring.
Design
Double blinded, randomised controlled trial.
Setting
Copenhagen Prospective Studies on Asthma in Childhood2010 cohort.
Participants
736 pregnant women and their offspring.
Intervention
n-3 LCPUFA (fish oil) or control (olive oil) daily from pregnancy week 24 until one week after birth.
Main outcome measures
Height/length, weight, head, and waist measurements and body composition from dual energy x ray absorptiometry (all pre-specified secondary endpoints of the n-3 LCPUFA trial; the primary outcome for the trial was persistent wheeze/asthma).
Results
The mean body mass index (BMI) z score was increased between age 0 and 6 years in the fish oil supplementation group compared with the control group (0.14 (95% confidence interval 0.04 to 0.23); P=0.006). At 6 years, supplementation was associated with a higher BMI z score (0.19 (0.06 to 0.32); P=0.004), a higher weight/height (3.48 (0.38 to 6.57) g/cm; P=0.03), and a larger waist circumference (0.6 (0.0 to 1.2) cm; P=0.04) but not a higher proportion of obese children, using International Obesity Task Force grades. The dual energy x ray absorptiometry scan at age 6 years showed a higher total mass (395.4 (86.6 to 704.3) g; P=0.01) in the supplementation versus the control group, explained by a higher lean mass (280.7 (98.9 to 462.4) g; P=0.002), a higher bone mineral content (10.3 (2.3 to 18.1) g; P=0.01), and a non-significantly higher fat mass (116.3 (-92.9 to 325.5) g; P=0.28), but no differences were seen in total body fat or lean mass percentage.
Conclusion
Fish oil supplementation from the 24th week of pregnancy led to a higher BMI in the offspring from 0 to 6 years of age but not an increased risk of obesity at age 6. The body composition at age 6 years in children given fish oil supplementation was characterised by a proportional increase in lean, bone, and fat mass suggesting a general growth stimulating effect of n-3 LCPUFA.
Trial registration
Clinicaltrials.gov NCT00798226.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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