Consumption of red and processed meat and breast cancer incidence: A systematic review and meta-analysis of prospective studies
Farvid MS, Stern MC, Norat T, Sasazuki S, Vineis P, Weijenberg MP, Wolk A, Wu K, Stewart BW, Cho E
International journal of cancer · 94 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (P30 CA014089)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-09-05 · Int J Cancer · vol. 143 · número 11 · págs. 2787–2799
- Editorial
- Wiley
- Citado
- 140 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Nutrition, Genetics, and Disease · Phytoestrogen effects and research
- Palabras clave
- Medicine, Breast cancer, Prospective cohort study, Odds ratio, Red meat, Relative risk, Incidence (geometry), Meta-analysis, Cohort study, Confidence interval, Internal medicine, Cancer, Pathology
- MeSH
- humans, breast neoplasms, incidence, risk factors, epidemiologic studies, case-control studies, prospective studies, meat products, databases, factual, adult, aged, middle aged, female, young adult, observational studies as topic, red meat
10 autores
- Maryam Sadat Farvid🇺🇸 · autor de correspondenciaHarvard University
- Mariana Carla Stern🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Teresa Norat🇬🇧Imperial College London
- Shizuka Sasazuki🇺🇸Prevention Group
- Paolo Vineis🇬🇧🇮🇹Public Health England; Italian institute for Genomic Medicine; Imperial College London
- Matty P. Weijenberg🇳🇱Maastricht University; Maastro Clinic
- Alicja Wolk🇸🇪Karolinska Institutet
- Kana Wu🇺🇸Harvard University
- Bernard W. Stewart🇦🇺UNSW Sydney; Women's & Children's Health Research Institute; Women's and Children's Health Network
- Eunyoung Cho🇺🇸Brigham and Women's Hospital; Harvard University; Brown University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Prior studies on red and processed meat consumption with breast cancer risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective studies to summarize the evidence regarding the relation of red meat and processed meat consumption with breast cancer incidence. We searched in MEDLINE and EMBASE databases through January 2018 for prospective studies that reported the association between red meat and processed meat consumption with incident breast cancer. The multivariable-adjusted relative risk (RR) was combined comparing the highest with the lowest category of red meat (unprocessed) and processed meat consumption using a random-effect meta-analysis. We identified 13 cohort, 3 nested case-control and two clinical trial studies. Comparing the highest to the lowest category, red meat (unprocessed) consumption was associated with a 6% higher breast cancer risk (pooled RR,1.06; 95% confidence intervals (95%CI):0.99-1.14; I2 = 56.3%), and processed meat consumption was associated with a 9% higher breast cancer risk (pooled RR, 1.09; 95%CI, 1.03-1.16; I2 = 44.4%). In addition, we identified two nested case-control studies evaluating the association between red meat and breast cancer stratified by N-acetyltransferase 2 acetylator genotype. We did not observe any association among those with either fast (per 25 g/day pooled odds ratio (OR), 1.18; 95%CI, 0.93-1.50) or slow N-acetyltransferase 2 acetylators (per 25 g/day pooled OR, 0.99; 95%CI, 0.91-1.08). In the prospective observational studies, high processed meat consumption was associated with increased breast cancer risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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