Synergism between luteolin and sulforaphane in anti-inflammation
Rakariyatham K, Wu X, Tang Z, Han Y, Wang Q, Xiao H
Food & function · 37 citas
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Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- U.S. Department of Agriculture (2014-67021); National Natural Science Foundation of China (31671858); U.S. Department of Agriculture (MAS00492); U.S. Department of Agriculture (MAS00450)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-01-01 · Food Funct · vol. 9 · número 10 · págs. 5115–5123
- Editorial
- Royal Society of Chemistry
- Citado
- 52 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Immune Cell Function and Interaction · Reproductive System and Pregnancy
- Palabras clave
- Sulforaphane, Luteolin, Inflammation, Lipopolysaccharide, Chemistry, Pharmacology, Biochemistry, Medicine, Immunology, Flavonoid, Antioxidant
- MeSH
- macrophages, animals, humans, mice, inflammation, reactive oxygen species, isothiocyanates, sulfoxides, luteolin, nf-kappa b, anti-inflammatory agents, drug synergism, nf-e2-related factor 2, cyclooxygenase 2, heme oxygenase-1, interleukin-1beta, raw 264.7 cells
6 autores
- Kanyasiri Rakariyatham🇺🇸Amherst College; University of Massachusetts Amherst
- Xian Wu🇺🇸Amherst College; University of Massachusetts Amherst
- Zhonghai Tang🇨🇳🇬🇧Changsha University; Institute of Food Science & Technology; Hunan Agricultural University
- Yanhui Han🇺🇸Amherst College; University of Massachusetts Amherst
- Qi Wang🇺🇸Amherst College; University of Massachusetts Amherst
- Hang Xiao🇨🇳🇺🇸🇬🇧 · autor de correspondenciaChangsha University; University of Massachusetts Amherst; Institute of Food Science & Technology; Hunan Agricultural University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Luteolin and sulforaphane are well-known food bioactives with anti-inflammatory properties. Herein, we determined their combinational effects in inhibiting inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Both luteolin and sulforaphane showed dose-dependent inhibition on LPS-induced production of nitric oxide (NO) in the macrophages. The combined treatments led to a stronger inhibition on NO production compared to the singular treatments. Isobologram analysis confirmed that the combined treatments produced a synergy. Western blotting and ELISA showed that the combined treatment reduced the expression levels of pro-inflammatory proteins involving NF-κB pathway, and STAT3 activation, which regulated expression of other inflammatory proteins such as iNOS, COX-2, IL-6, and IL-1β. Moreover, the combination treatments reduced reactive oxygen species in cells and increased the expression of Nrf2 and HO-1, which are cellular antioxidant proteins. In conclusion, our findings support the notion that certain bioactive food components may act synergistically to produce enhanced health effects such as anti-inflammation.
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