Adiposity mediates the association between whole grain consumption, glucose homeostasis and insulin resistance: findings from the US NHANES
Mazidi M, Katsiki N, Kengne AP, Mikhailidis DP, Banach M
Lipids in health and disease · 14 citas
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- Financiación independiente
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Publicación
- Publicado
- 2018-09-17 · Lipids Health Dis · vol. 17 · número 1 · pág. 219
- Editorial
- BioMed Central
- Citado
- 18 citas · más que el 80% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Phytoestrogen effects and research
- Palabras clave
- Internal medicine, Insulin resistance, Endocrinology, Triglyceride, Medicine, Body mass index, Homeostatic model assessment, Clinical nutrition, Glucose homeostasis, National Health and Nutrition Examination Survey, Waist, Metabolic syndrome, Insulin, Obesity, Cholesterol, Population
- MeSH
- humans, insulin resistance, insulin, blood glucose, triglycerides, glucose tolerance test, body mass index, nutrition surveys, adult, middle aged, female, male, intra-abdominal fat, adiposity, waist circumference, obesity, abdominal, whole grains
5 autores
- Mohsen Mazidi🇨🇳 · autor de correspondenciaChinese Academy of Sciences; Institute of Genetics and Developmental Biology
- Niki Katsiki🇬🇷Aristotle University of Thessaloniki
- André Pascal Kengne🇿🇦South African Medical Research Council; University of Cape Town
- Dimitri P. Mikhailidis🇬🇧The Royal Free Hospital; University College London
- Maciej Banach🇵🇱Medical University of Lodz; Polish Mother’s Memorial Hospital Research Institute; University of Zielona Góra
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Growing evidence suggests an inverse association between whole grain (WG) consumption and insulin resistance (IR) or inflammation. However, it is still unclear whether adiposity plays a role in this relationship. We investigated whether the associations between WG intake with IR, glucose homeostasis and inflammation are mediated by adiposity in US adults.
Methods
The 2005-2010 National Health and Nutrition Examination Surveys participants were included. WG intake was assessed and markers of IR and glucose homeostasis, inflammation, general and central adiposity. Analysis of co-variance and mediation analysis were applied, while accounting for survey design.
Results
Overall 16,621 participants were included in this analysis (mean age = 47.1 years, 48.3% men). After adjustment for age, gender, and race, mean C-reactive protein (CRP), apolipoprotein B (apo-B), fasting blood glucose (FBG), insulin, homeostatic model assessment of IR (HOMA-IR) and β cell function (HOMA-β), hemoglobin A1c (HbA1c), and 2 h glucose after an oral glucose tolerance test decreased with increasing quarters of WG (all p 1c, triglyceride to high density lipoprotein-cholesterol (TG:HDL-C) ratio and triglyceride-glucose (TyG) index (all p 1c, TG:HDL-C ratio and TyG index, i.e. WC and apVAT had indirect effect (all p < 0.05).
Conclusion
Our findings provide insights into the favourable impact of WG consumption on IR and inflammation, which may be affected by both central and visceral adiposity, i.e. the link between WG with IR and inflammation is more mediated in overweight/obese compared with lean individuals.
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