Walnut ( Juglans regia) Peptides Reverse Sleep Deprivation-Induced Memory Impairment in Rat via Alleviating Oxidative Stress
Wang S, Su G, Zhang Q, Zhao T, Liu Y, Zheng L, Zhao M
Journal of agricultural and food chemistry · 58 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Gobierno
- Government of Guangdong Province
- Gobierno
- Ministry of Human Resources and Social Security
- Gobierno
- Guangzhou Science and Technology Plan Projects
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Subvenciones
- Government of Guangdong Province (2016TQ03N728); Ministry of Human Resources and Social Security (BX201700081); Ministry of Science and Technology of the People's Republic of China (2017YFD0400201)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2018-09-18 · J Agric Food Chem · vol. 66 · número 40 · págs. 10617–10627
- Editorial
- American Chemical Society
- Citado
- 91 citas · más que el 87% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Protein Hydrolysis and Bioactive Peptides · Biochemical effects in animals · Fatty Acid Research and Health
- Palabras clave
- Neuroprotection, Oxidative stress, Superoxide dismutase, Malondialdehyde, Glutathione peroxidase, Pharmacology, Chemistry, Antioxidant, Glutamate receptor, Biochemistry, Reactive oxygen species, Glutathione, Viability assay, Apoptosis, Biology, Enzyme
- MeSH
- pc12 cells, animals, humans, rats, juglans, sleep deprivation, reactive oxygen species, malondialdehyde, catalase, glutathione peroxidase, superoxide dismutase, peptides, neuroprotective agents, memory, apoptosis, oxidative stress, female, male, membrane potential, mitochondrial
7 autores
- Shuguang Wang🇨🇳South China University of Technology
- Guowan Su🇨🇳South China University of Technology
- Qi Zhang🇨🇳South China University of Technology
- Tiantian Zhao🇨🇳South China University of Technology
- Yang Liu🇨🇳South China University of Technology
- Lin Ping Zheng🇨🇳 · autor de correspondenciaSouth China University of Technology
- Mouming Zhao🇨🇳 · autor de correspondenciaBeijing Technology and Business University; Beijing Advanced Innovation Center for Food Nutrition and Human Health; South China University of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study was to determine the neuroprotective effects of walnut protein hydrolysates (WPH) against memory deficits induced by sleep deprivation (SD) in rat and further to identify and characterize the potent neuroprotective peptides against glutamate-induced apoptosis in PC12 cells. Results showed that a remarkable amelioration effect on behavioral performance in Morris water maze test was observed for WPH and its low molecular weight fraction WPHL, especially for WPHL. Additionally, a reduction of antioxidant defense (catalase, glutathione peroxidase (GSH-px), and superoxide dismutase (SOD)) and an increase of malondialdehyde content induced by SD were normalized in brain of rat after oral administration of WPH and WPHL. Then three neuroprotective peptides including GGW, VYY, and LLPF were identified from WPHL, which could protect PC12 cells against glutamate-induced apoptosis with relative cell viability of 78.29 ± 3.09%, 80.65 ± 1.74%, and 83.97 ± 3.06%, respectively, versus glutamate group 48.61 ± 3.99%. The possible mechanism underlying their protective effects of GGW and VYY could be related to their strong radical scavenging activity as well as their ability to reduce reactive oxygen species production and the depletion of SOD and GSH-px in PC12 cells. Notably, the marked neuroprotective effects of LLPF, which did not show obvious free-radical scavenging activity in vitro, could be attributed to its strong effects on inhibiting Ca2+ influx and mitochondrial membrane potential collapse. Additionally, all these peptides could regulate the expression of apoptosis-related proteins (Bax and Bcl-2). Therefore, walnut peptides might be regarded as the potential nutraceuticals against neurodegenerative disorders associated with memory deficits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.