Association between whole grain intake and breast cancer risk: a systematic review and meta-analysis of observational studies
Xiao Y, Ke Y, Wu S, Huang S, Li S, Lv Z, Yeoh EK, Lao X, Wong S, Kim JH, Colditz GA, Tamimi RM, Su X
Nutrition journal · 33 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Hong Kong Research Grants Council General Research Fund
- Subvenciones
- National Natural Science Foundation of China (81402672)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-09-21 · Nutr J · vol. 17 · número 1 · pág. 87
- Editorial
- BioMed Central
- Citado
- 51 citas · más que el 66% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 77 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Celiac Disease Research and Management · Nutritional Studies and Diet
- Palabras clave
- Medicine, Meta-analysis, Breast cancer, Relative risk, Subgroup analysis, Confidence interval, Internal medicine, Observational study, Cohort study, Publication bias, Cochrane Library, Epidemiology, Cancer, Oncology
- MeSH
- humans, breast neoplasms, diet, risk factors, adult, aged, middle aged, female, observational studies as topic, whole grains
13 autores
- Yunjun Xiao🇨🇳Shenzhen Center for Disease Control and Prevention
- Yuebin Ke🇨🇳Shenzhen Center for Disease Control and Prevention
- Shuang Wu🇨🇳Shenzhen Center for Disease Control and Prevention
- Suli Huang🇨🇳Shenzhen Center for Disease Control and Prevention
- Siguo Li🇨🇳Shenzhen Center for Disease Control and Prevention
- Ziquan Lv🇨🇳Shenzhen Center for Disease Control and Prevention
- Eng‐Kiong Yeoh🇭🇰🇨🇳Chinese University of Hong Kong; Prince of Wales Hospital
- Xiang Qian Lao🇭🇰🇨🇳Chinese University of Hong Kong; Prince of Wales Hospital
- Samuel W. K. Wong🇭🇰🇨🇳Chinese University of Hong Kong; Prince of Wales Hospital
- Jean Hee Kim🇭🇰🇨🇳Chinese University of Hong Kong; Prince of Wales Hospital
- Graham A. Colditz🇺🇸Alvin J. Siteman Cancer Center
- Rulla M. Tamimi🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Xuefen Su🇭🇰🇨🇳 · autor de correspondenciaChinese University of Hong Kong; Prince of Wales Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological studies have found that high whole grain intake may be associated with a reduced risk of breast cancer. However, the evidence has not been consistent. We conducted a meta-analysis to quantitatively assess the association between whole grain intake and breast cancer risk.
Methods
Relevant observational studies were identified by searching PubMed, Embase, Cochrane library databases, and Google Scholar through April 2017. Summary relative risk (RR) estimates were calculated using random-effects meta-analysis.
Results
A total of 11 studies, including 4 cohort and 7 case-control studies and involving 131,151 participants and 11,589 breast cancer cases, were included in the current meta-analysis. The pooled RR of breast cancer for those with high versus low whole grain intake was 0.84 (95% confidence interval [CI]: 0.74 to 0.96, p = 0.009; I2 = 63.8%, p for heterogeneity = 0.002). Subgroup analysis by study design found a significant inverse association in the case-control studies (RR: 0.69; 95% CI: 0.56 to 0.87, p = 0.001; I2 = 58.2%, p for heterogeneity = 0.026), but not in the cohort studies (RR, 0.96; 95% CI: 0.82 to 1.14, p = 0.69; I2 = 66.7%, p for heterogeneity = 0.029). In addition, stratified analysis suggested that sample size could be a potential source of heterogeneity.
Conclusions
Results of the current meta-analysis suggest that high intake of whole grains might be inversely associated with a reduced risk of breast cancer, and the inverse association was only observed in case-control but not cohort studies. More large-scale cohort studies are needed to confirm the inverse association observed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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