Transcranial and systemic photobiomodulation for major depressive disorder: A systematic review of efficacy, tolerability and biological mechanisms
Caldieraro MA, Cassano P
Journal of affective disorders · 75 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-09-17 · J Affect Disord · vol. 243 · págs. 262–273
- Editorial
- Elsevier BV
- Citado
- 134 citas · más que el 81% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 121 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Treatment of Major Depression · Transcranial Magnetic Stimulation Studies
- Palabras clave
- low-level laser therapy, major depressive disorder, transcranial photobiomodulation, red and near-infrared light, mitochondrial metabolism, cytochrome c oxidase, antidepressant effects, tolerability, mechanism of action, animal models of depression
- MeSH
- mitochondria, animals, humans, infrared rays, low-level light therapy, major depressive disorder
2 autores
- Marco Antônio Caldieraro🇧🇷 · autor de correspondenciaHospital de Clínicas de Porto Alegre
- Paolo Cassano🇺🇸Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light Therapy-is a low risk, inexpensive treatment-based on non-retinal exposure-under study for several neuropsychiatric conditions. The aim of this paper is to discuss the proposed mechanism of action and to perform a systematic review of pre-clinical and clinical studies on PBM for major depressive disorder (MDD).
Methods
A search on MEDLINE and EMBASE databases was performed in July 2017. No time or language restrictions were used. Studies with a primary focus on MDD and presenting original data were included (n = 17). References on the mechanisms of action of PBM also included review articles and studies not focused on MDD.
Results
Red and NIR light penetrate the skull and modulate brain cortex; an indirect effect of red and NIR light, when delivered non-transcranially, is also postulated. The main proposed mechanism for PBM is the enhancement of mitochondrial metabolism after absorption of NIR energy by the cytochrome C oxidase; however, actions on other pathways relevant to MDD are also reported. Studies on animal models indicate a benefit from PBM that is comparable to antidepressant medications. Clinical studies also indicate a significant antidepressant effect and good tolerability.
Limitations
Clinical studies are heterogeneous for population and treatment parameters, and most lack an appropriate control.
Conclusions
Preliminary evidence supports the potential of non-retinal PBM as a novel treatment for MDD. Future studies should clarify the ideal stimulation parameters as well as the overall efficacy, effectiveness and safety profile of this treatment.
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