Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial
Chen L, Dong Y, Bhagatwala J, Raed A, Huang Y, Zhu H
The journals of gerontology. Series A, Biological sciences and medical sciences · 93 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL131674); American Heart Association (14GRNT20480211)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2018-09-25 · J Gerontol A Biol Sci Med Sci · vol. 74 · número 1 · págs. 91–98
- Editorial
- Oxford University Press
- Citado
- 115 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Epigenetics and DNA Methylation · Skin Protection and Aging
- Palabras clave
- vitamin D3 supplementation, epigenetic aging, DNA methylation, Horvath epigenetic clock, obesity, overweight, African Americans, 25-hydroxyvitamin D, biological aging
- MeSH
- humans, obesity, cholecalciferol, telomerase, vitamins, incidence, retrospective studies, follow-up studies, double-blind method, dna methylation, epigenesis, genetic, aging, dietary supplements, adolescent, adult, middle aged, georgia, female, male, overweight, young adult, black or african american
6 autores
- Li Chen
- Yanbin Dong
- Jigar Bhagatwala🇺🇸Augusta University
- Anas Raed🇺🇸Augusta University
- Ying Huang
- Haidong Zhu · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We have previously shown that vitamin D supplementation increases telomerase activity, suggesting an anti-aging effect. In this study, we aim to test the hypothesis that vitamin D supplementation would slow down epigenetic aging, a new marker of biological aging.
Methods
A randomized clinical trial was previously conducted among 70 overweight/obese African Americans with serum 25-hydroxyvitamin D [25(OH)D] < 50 nmol/L, who were randomly assigned into four groups of 600 IU/d, 2,000 IU/d, 4,000 IU/d of vitamin D3 supplements or placebo followed by 16-week interventions. Whole genome-wide DNA methylation analysis was conducted in 51 participants. DNA methylation ages were calculated according to the Horvath and the Hannum methods. Methylation-based age acceleration index (∆Age) is defined as the difference between DNA methylation age and chronological age in years. Mixed-effects models were used to evaluate the treatment effects.
Results
Fifty-one participants (aged 26.1 ± 9.3 years, 16% are male) were included in the study. After the adjustment of multi-covariates, vitamin D3 supplementation of 4,000 IU/d was associated with 1.85 years decrease in Horvath epigenetic aging compared with placebo (p value = .046), and 2,000 IU/d was associated with 1.90 years decrease in Hannum epigenetic aging (p value = .044). Serum 25(OH)D concentrations were significantly associated with decreased Horvath ∆Age only (p values = .002), regardless of treatments.
Conclusions
Our results suggest that vitamin D supplementation may slow down Horvath epigenetic aging. But the effect on Hannum epigenetic aging is not conclusive. Large-scale and longer duration clinical trials are needed to replicate the findings.
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