Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review
Fulton JL, Dinas PC, Carrillo AE, Edsall JR, Ryan EJ, Ryan EJ
Nutrients · 50 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-09-25 · Nutrients · vol. 10 · número 10 · pág. 1373
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 69 citas · más que el 72% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Eating Disorders and Behaviors
- Palabras clave
- Caffeine, Single-nucleotide polymorphism, Medicine, rs4680, CYP1A2, Pharmacology, Biology, Physiology, Genetics, Genotype, Psychiatry, Internal medicine, Gene, Cytochrome P450
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, receptor, adenosine a2a, receptors, aryl hydrocarbon, anxiety, genotype, polymorphism, single nucleotide, adult, middle aged, female, male, performance-enhancing substances, pharmacogenomic variants, basic helix-loop-helix proteins
6 autores
- Jacob L. Fulton🇺🇸Chatham University
- Petros C. Dinas🇬🇷University of Thessaly
- Andres E. Carrillo🇬🇷🇺🇸University of Thessaly; Chatham University
- Jason R. Edsall🇺🇸Chatham University
- Emily J. Ryan🇺🇸West Virginia University; Chatham University
- Edward J. Ryan🇺🇸 · autor de correspondenciaWest Virginia University; Chatham University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Emerging research has demonstrated that genetic variation may impact physiological responses to caffeine consumption. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. Two databases (PubMed and EBSCO) were independently searched using the same algorithm. Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption. Several studies demonstrated that the anxiogenic consequences of caffeine differed across adenosine 2a receptor (ADORA2A) genotypes, and the studies that investigated the effects of genetic variation on the ergogenic benefit of caffeine reported equivocal findings (CYP1A2) or warrant replication (ADORA2A).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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