Effects of Laser Photobiomodulation and Ozone Therapy on Palatal Epithelial Wound Healing and Patient Morbidity
Isler SC, Uraz A, Guler B, Ozdemir Y, Cula S, Cetiner D
Photomedicine and laser surgery · 41 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-09-27 · Photomed Laser Surg · vol. 36 · número 11 · págs. 571–580
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 73 citas · más que el 93% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Dental Implant Techniques and Outcomes
- Palabras clave
- Medicine, Visual analogue scale, Digital image analysis, Low level laser therapy, Ozone therapy, Laser therapy, Dentistry, Wound healing, Surgery, Clinical efficacy, Laser, Pathology
- MeSH
- mouth mucosa, palate, humans, gingival recession, hydrogen peroxide, ozone, pain measurement, treatment outcome, combined modality therapy, prospective studies, wound healing, adult, turkey, female, male, transplant donor site, re-epithelialization, low-level light therapy
6 autores
- Sıla Çağrı İşler🇹🇷Gazi University
- Ahu Uraz🇹🇷Gazi University
- Berceste Güler🇹🇷Kütahya Dumlupınar Üniversitesi
- Yücel Özdemir🇹🇷Gazi University
- Serpil Cula🇹🇷Başkent University
- Deniz Çetiner🇹🇷 · autor de correspondenciaGazi University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study was to compare the effects of laser photobiomodulation (PBM) and topical ozone therapy on the reepithelialization of palatal donor site wounds through clinical assessment and computer-aided image analysis and to assess the patient morbidity following free gingival graft (FGG) surgeries.
Material and methods
Thirty-six patients requiring FGG were randomly allocated into three groups: laser group (n = 12), ozone group (n = 12), and control group (n = 12). Epithelialization was evaluated by applying 3% hydrogen peroxide (H2O2) to the wound area and also measured by using digital image analysis (ImageJ). Bland-Altman plots were used for assessing agreement between H2O2 and ImageJ measurements. Parameters in relation to patient morbidity were assessed by using visual analog scale (VAS) on the first 3, 7, 14, and 30 days postoperatively.
Results
At day 14, statistically significant smaller wounds were observed with digital image analysis in the ozone group as compared with the control group (p = 0.034). However, intergroup comparison of the remaining wound area evaluated by the clinician using the H2O2 method did not reveal any significant differences (p > 0.05). Nonetheless, according to Bland-Altman analysis, the lower and upper limits showed a moderate agreement between the two measurement methods. The mean VAS sores exhibiting postoperative discomfort was observed to be significantly higher in the control group compared with the laser group (p = 0.002) and ozone group (p < 0.001) at day 7.
Conclusions
Adjunctive ozone therapy could have a significantly beneficial effect on the acceleration of palatal wound healing following FGG procedures. Both PBM and ozone treatment modalities reduced postoperative discomfort as compared with spontaneous healing.
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