The Acute Effect of Oleic- or Linoleic Acid-Containing Meals on Appetite and Metabolic Markers; A Pilot Study in Overweight or Obese Individuals
Naughton SS, Hanson ED, Mathai ML, McAinch AJ
Nutrients · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-09-26 · Nutrients · vol. 10 · número 10 · pág. 1376
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 23 citas · más que el 81% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 78 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Regulation of Appetite and Obesity · Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- oleic acid, linoleic acid, dietary fatty acids, appetite, ghrelin, resistin, insulin signaling, postprandial fullness, dietary intake, overweight, obesity, glucose handling
- MeSH
- humans, obesity, insulin, dietary fats, linoleic acid, oleic acid, pilot projects, cross-over studies, single-blind method, appetite, satiety response, eating, postprandial period, adult, middle aged, female, male, overweight, ghrelin, meals
4 autores
- Shaan Naughton🇦🇺Victoria University
- Erik D. Hanson🇦🇺Victoria University
- Michael L. Mathai🇦🇺The University of Melbourne; Florey Institute of Neuroscience and Mental Health; Victoria University
- Andrew J. McAinch🇦🇺 · autor de correspondenciaAustralian Institute for Musculoskeletal Science; Victoria University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Despite the abundance of plant-derived fats in our diet, their effects on appetite, and metabolic markers, remain unclear. This single-blinded 3-way cross-over pilot study aimed to investigate the ability of the two most abundant dietary plant-derived fats, oleic (OA) and linoleic (LA) acids, to modulate postprandial appetite and levels of circulating appetite and metabolic regulators in overweight/obese individuals. Meals were a high-carbohydrate control, a high-OA or a high-LA meal, and provided 30% of participants' estimated energy requirements. Meals were consumed after an overnight fast, with blood samples collected over 3¼ h. Appetite parameters were assessed via a validated visual analogue scale questionnaire. Hormones and other circulating factors were quantified using multiplex immunoassays. Eight participants (age 45.8 ± 3.6 (years), body mass index 32.0 ± 1.3 (kg/m²)) completed the study. All meals significantly increased fullness and reduced desire to eat. The control and high-OA meals significantly decreased prospective food intake. The high-LA meal increased ghrelin levels (p < 0.05), a hormone which encourages food intake. This was coupled with a significant acute increase in resistin levels, which impairs insulin signaling. Taken together, this study indicates that in overweight/obese individuals, high-LA meals may promote excess energy intake and alter glucose handling, though a larger cohort may be required to strengthen results.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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