Financiado en parte por ASA srl
Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients
Robijns J, Censabella S, Claes S, Pannekoeke L, Bussé L, Colson D, Kaminski I, Lodewijckx J, Bulens P, Maes A, Noé L, Brosens M, Timmermans A, Lambrichts I, Somers V, Mebis J
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 35 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- Kom op tegen Kanker
- Organización sin fines de lucro
- Limburgs Kankerfonds
- Empresa
- ASA srl
- Universidad u hospital
- Limburg Clinical Research Program
Según 4 financiadores declarados.
Publicación
- Publicado
- 2018-09-30 · Support Care Cancer · vol. 27 · número 4 · págs. 1245–1254
- Editorial
- Springer Science+Business Media
- Citado
- 40 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Chemotherapy-related skin toxicity · Laser Applications in Dentistry and Medicine · Effects of Radiation Exposure
- Palabras clave
- low-level laser therapy, acute radiation dermatitis, breast cancer, radiotherapy, moist desquamation, transepidermal water loss, skin barrier function, skin pigmentation, melanin, erythema, breast volume, risk factors
- MeSH
- breast, skin, humans, breast neoplasms, radiodermatitis, hypertrophy, acute disease, prognosis, treatment outcome, combined modality therapy, radiotherapy, adjuvant, mastectomy, segmental, risk factors, adult, aged, middle aged, female, secondary prevention, biophysical phenomena, low-level light therapy
16 autores
- Jolien Robijns🇧🇪 · autor de correspondenciaHasselt University
- Sandrine Censabella🇧🇪Jessa Hospital
- Stefan Claes🇧🇪Jessa Hospital
- Luc Pannekoeke🇧🇪Jessa Hospital
- Lore Bussé🇧🇪Hasselt University
- Dora Colson🇧🇪Hasselt University
- Iris Kaminski🇧🇪Hasselt University
- Joy Lodewijckx🇧🇪Hasselt University
- Paul Bulens🇧🇪Jessa Hospital
- Annelies Maes🇧🇪Jessa Hospital
- Leen Noé🇧🇪Jessa Hospital
- Marc Brosens🇧🇪Jessa Hospital
- An Timmermans🇧🇪Jessa Hospital
- Ivo Lambrichts🇧🇪Hasselt University
- Veerle A Somers🇧🇪Hasselt University
- Jeroen Mebis🇧🇪Jessa Hospital; Hasselt University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of this study was to evaluate objectively the effectiveness of photobiomodulation therapy (PBMT) for the prevention of acute radiation dermatitis (ARD) by using biophysical skin measurements.
Methods
A randomized, placebo-controlled trial with 120 breast cancer patients who underwent an identical radiotherapy (RT) regimen post-lumpectomy was performed (TRANSDERMIS trial). Patients were randomized to receive PBM (808 nm CW/905 nm pulsed, 168 mW/cm2, spot size 19.6 cm2, fluence 4 J/cm2) or placebo treatments from the first day of RT (2×/week). Biophysical skin measurements were collected to assess the skin pigmentation and barrier function. Measurements were collected at the first day of RT, a RT dose of 40 Gray (Gy), and the end of RT (66 Gy).
Results
The incidence of moist desquamation was significantly higher in the control than in the PBMT group at the end of RT (30 vs. 7%, respectively, odds ratio = 6, p = 0.004). The biophysical skin measures showed that the mean percentage change from the baseline transepidermal water loss (TEWL), erythema, and melanin values was significantly higher in the control than in the PBMT group at the end of RT (ps 800 cc) breast volume (odds ratio = 4, p = 0.017).
Conclusions
This is the first randomized controlled trial demonstrating by objective measurements that PBMT is effective in reducing the incidence of moist desquamation in breast cancer patients undergoing RT. Additionally, a large breast volume is an important risk factor for the development of moist desquamation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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