The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis
Gao Q, Kou T, Zhuang B, Ren Y, Dong X, Wang Q
Nutrients · 140 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Medical Science and Technology Development project
- Subvenciones
- National Natural Science Foundation of China (81472983)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-10-01 · Nutrients · vol. 10 · número 10 · pág. 1395
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 190 citas · más que el 95% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 77 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Sleep and related disorders · Circadian rhythm and melatonin
- Palabras clave
- vitamin D deficiency, sleep disorders, sleep quality, short sleep duration, daytime sleepiness, 25-hydroxyvitamin D, serum vitamin D levels
- MeSH
- humans, vitamin d deficiency, vitamin d, odds ratio, risk factors, case-control studies, cohort studies, cross-sectional studies, sleep, adolescent, adult, aged, middle aged, child, child, preschool, female, male, young adult, sleep wake disorders
6 autores
- Qi Gao🇨🇳Qingdao University
- Tingyan Kou🇨🇳Qingdao University
- Bin Zhuang🇨🇳Qingdao University
- Ren Yangyang🇨🇳Qingdao University
- Xue Zhen Dong🇨🇳Qingdao University
- Qiuzhen Wang🇨🇳 · autor de correspondenciaQingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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