Sulforaphane Normalizes Intestinal Flora and Enhances Gut Barrier in Mice with BBN-Induced Bladder Cancer
He C, Huang L, Lei P, Liu X, Li B, Shan Y
Molecular nutrition & food research · 69 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Glasgow
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Heilongjiang University of Chinese Medicine
- Subvenciones
- National Natural Science Foundation of China (81773427)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-10-10 · Mol Nutr Food Res · vol. 62 · número 24 · pág. e1800427
- Editorial
- Wiley
- Citado
- 81 citas · más que el 89% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Gut microbiota and health · Immune cells in cancer
- Palabras clave
- Sulforaphane, Bladder cancer, Gut flora, Cruciferous vegetables, Tight junction, Inflammation, Dysbiosis, Cancer, Colorectal cancer, Cancer research, Immune system, Carcinogenesis, Nitrosamine, Immunology, Medicine, Chemistry, Internal medicine, Carcinogen, Biochemistry
- MeSH
- caco-2 cells, animals, mice, inbred c57bl, humans, butyric acid, isothiocyanates, butylhydroxybutylnitrosamine, sulfoxides, immunoglobulin a, secretory, anticarcinogenic agents, interleukin-6, male, urinary bladder neoplasms, tight junction proteins, gastrointestinal microbiome
6 autores
- Canxia He🇨🇳Harbin Institute of Technology
- Lei Huang🇨🇳Harbin Institute of Technology
- Lei Peng🇨🇳Harbin Institute of Technology
- Xiaodong Liu🇨🇳Harbin Institute of Technology
- Bao‐Long Li🇨🇳 · autor de correspondenciaHeilongjiang University of Chinese Medicine
- Yujuan Shan🇨🇳 · autor de correspondenciaHarbin Institute of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Gut microbiota imbalance, inflammation, and gut barrier deficiency play an important role in carcinogenesis. Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has been proven to be highly effective in inhibiting cancer. The objective of this study is to investigate the potential roles of the gut microbiota in the inhibition of BBN-induced bladder cancer by SFN.
Methods and results
N-butyl-N-(4-hydroxybutyl)-nitrosamine is used to induce bladder cancer in male C57BL/6 mice, with or without SFN for 23 weeks. SFN ameliorates the histological changes characteristic of bladder cancer, resulting in fewer submucosal capillaries. SFN normalizes gut microbiota dysbiosis in mice with BBN-induced bladder cancer with a significant increase in Bacteroides fragilis and Clostridium cluster I. SFN also increases butyric acid levels in the mouse colon, and repairs the injury to the mucosal epithelium of the colon and cecum through the upregulation of the expression of tight junction proteins and GLP2. SFN greatly decreases the release of cytokines (IL-6) and secretory immunoglobulin A in the mice with bladder cancer.
Conclusion
These results suggest that SFN protects against chemical-induced bladder cancer through normalizing the composition of gut microbiota and repairing the physiological destruction of the gut barrier, as well as decreasing inflammation and the immune response.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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